A clinical study of the immunogenicity and protective potency of a live recombinant GamLPV vaccine for intranasal use for the prevention of whooping cough in adult volunteers

A clinical study of the immunogenicity and protective potency of a live recombinant GamLPV vaccine for intranasal use for the prevention of whooping cough in adult volunteers

Introduction. The increase in incidence rate of pertussis worldwide, short-term insufficient immunity induced by acellular pertussis vaccines (TDaP) and their failure to provide antibacterial protection and to prevent transmission of infection in human population dictate the development of new pertu...

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Main Authors: Alevtina A. Lidzhieva, Alisa Yu. Medkova, Sergey V. Kulikov, Ludmila N. Sinyashina, Rezida A. Sioundioukova, Andrey P. Markov, Aleksey B. Verveda, Natalia E. Abaeva, Irina N. Chernyshova, Marina V. Gavrilova, Kristina K. Bushkova, Ilya N. Dyakov, Gennady I. Karataev
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2024-12-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
vaccine gamlpv
bordetella pertussis
multicenter clinical trial
volunteers
immunogenicity
protective potency
pertussis
humoral immune response
Online Access:https://microbiol.crie.ru/jour/article/viewFile/18724/1552
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