MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology
Contemporary biology has been revolutionized by a recently discovered class of small regulatory RNA molecules, microRNAs (miRNAs). Missed by researchers for decades due to their tiny size, usually mapping to non-protein-coding regions of genomes, miRNAs and miRNA-mediated regulatory networks have be...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.201 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549484902481920 |
|---|---|
| author | Anna M. Krichevsky |
| author_facet | Anna M. Krichevsky |
| author_sort | Anna M. Krichevsky |
| collection | DOAJ |
| description | Contemporary biology has been revolutionized by a recently discovered class of small regulatory RNA molecules, microRNAs (miRNAs). Missed by researchers for decades due to their tiny size, usually mapping to non-protein-coding regions of genomes, miRNAs and miRNA-mediated regulatory networks have been the “dark matter” of molecular biology. Deciphering miRNA pathways and functions in the CNS of complex organisms is tightly linked to understanding miRNA expression patterns. To facilitate these emerging studies, I here review the basic principles of medium- and high-throughput technologies available for miRNA expression profiling. |
| format | Article |
| id | doaj-art-fae727adf57549848ef2454c84e02442 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-fae727adf57549848ef2454c84e024422025-02-03T06:11:20ZengWileyThe Scientific World Journal1537-744X2007-01-01715516610.1100/tsw.2007.201MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in NeurobiologyAnna M. Krichevsky0Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USAContemporary biology has been revolutionized by a recently discovered class of small regulatory RNA molecules, microRNAs (miRNAs). Missed by researchers for decades due to their tiny size, usually mapping to non-protein-coding regions of genomes, miRNAs and miRNA-mediated regulatory networks have been the “dark matter” of molecular biology. Deciphering miRNA pathways and functions in the CNS of complex organisms is tightly linked to understanding miRNA expression patterns. To facilitate these emerging studies, I here review the basic principles of medium- and high-throughput technologies available for miRNA expression profiling.http://dx.doi.org/10.1100/tsw.2007.201 |
| spellingShingle | Anna M. Krichevsky MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology The Scientific World Journal |
| title | MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology |
| title_full | MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology |
| title_fullStr | MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology |
| title_full_unstemmed | MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology |
| title_short | MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology |
| title_sort | microrna profiling from dark matter to white matter or identifying new players in neurobiology |
| url | http://dx.doi.org/10.1100/tsw.2007.201 |
| work_keys_str_mv | AT annamkrichevsky micrornaprofilingfromdarkmattertowhitematteroridentifyingnewplayersinneurobiology |