Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes
Background. Type 1 diabetes (T1D) and type 2 diabetes (T2D) have been linked to Helicobacter pylori infection, although results are conflicting. No previous study addressed a possible link between H. pylori infection and latent autoimmune diabetes in adults (LADA). In this study, a correlation among...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7347065 |
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| author | Alessandro P. Delitala Giovanni M. Pes Hoda M. Malaty Gavino Pisanu Giuseppe Delitala Maria P. Dore |
| author_facet | Alessandro P. Delitala Giovanni M. Pes Hoda M. Malaty Gavino Pisanu Giuseppe Delitala Maria P. Dore |
| author_sort | Alessandro P. Delitala |
| collection | DOAJ |
| description | Background. Type 1 diabetes (T1D) and type 2 diabetes (T2D) have been linked to Helicobacter pylori infection, although results are conflicting. No previous study addressed a possible link between H. pylori infection and latent autoimmune diabetes in adults (LADA). In this study, a correlation among H. pylori infection and the risk of autoimmune diabetes in comparison with T2D was investigated. Methods. Sera from 234 LADA patients, 105 patients with late-onset T1D, and 156 patients with T2D were analyzed for anti-H. pylori and the cytotoxin-associated antigen (CagA) IgG antibodies. Results. H. pylori seroprevalence was comparable in LADA (52%), late-onset T1D (45%), and T2D (49%) with no gender differences. The seroprevalence of CagA IgG was significantly higher in autoimmune diabetes (late-onset T1D: 45%, LADA: 40%) compared to T2D (25%; p<0.028). Conclusions. Although H. pylori seroprevalence was similar in LADA, T1D, and T2D, anti-CagA positivity was significantly increased among patients with autoimmune diabetes, suggesting that more virulent H. pylori strains might be a trigger for immune mechanisms involved in their pathogenesis. |
| format | Article |
| id | doaj-art-fae3971d042e4fde930b493fcfa9545d |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-fae3971d042e4fde930b493fcfa9545d2025-02-03T01:07:21ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/73470657347065Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune DiabetesAlessandro P. Delitala0Giovanni M. Pes1Hoda M. Malaty2Gavino Pisanu3Giuseppe Delitala4Maria P. Dore5Azienda Ospedaliero Universitaria di Sassari, Sassari, ItalyDepartment of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 8, 07100 Sassari, ItalyBaylor College of Medicine, Houston, TX, USADepartment of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 8, 07100 Sassari, ItalyDepartment of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 8, 07100 Sassari, ItalyDepartment of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 8, 07100 Sassari, ItalyBackground. Type 1 diabetes (T1D) and type 2 diabetes (T2D) have been linked to Helicobacter pylori infection, although results are conflicting. No previous study addressed a possible link between H. pylori infection and latent autoimmune diabetes in adults (LADA). In this study, a correlation among H. pylori infection and the risk of autoimmune diabetes in comparison with T2D was investigated. Methods. Sera from 234 LADA patients, 105 patients with late-onset T1D, and 156 patients with T2D were analyzed for anti-H. pylori and the cytotoxin-associated antigen (CagA) IgG antibodies. Results. H. pylori seroprevalence was comparable in LADA (52%), late-onset T1D (45%), and T2D (49%) with no gender differences. The seroprevalence of CagA IgG was significantly higher in autoimmune diabetes (late-onset T1D: 45%, LADA: 40%) compared to T2D (25%; p<0.028). Conclusions. Although H. pylori seroprevalence was similar in LADA, T1D, and T2D, anti-CagA positivity was significantly increased among patients with autoimmune diabetes, suggesting that more virulent H. pylori strains might be a trigger for immune mechanisms involved in their pathogenesis.http://dx.doi.org/10.1155/2016/7347065 |
| spellingShingle | Alessandro P. Delitala Giovanni M. Pes Hoda M. Malaty Gavino Pisanu Giuseppe Delitala Maria P. Dore Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes Journal of Diabetes Research |
| title | Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes |
| title_full | Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes |
| title_fullStr | Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes |
| title_full_unstemmed | Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes |
| title_short | Implication of Cytotoxic Helicobacter pylori Infection in Autoimmune Diabetes |
| title_sort | implication of cytotoxic helicobacter pylori infection in autoimmune diabetes |
| url | http://dx.doi.org/10.1155/2016/7347065 |
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