Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation

Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation

Background: Sympathetic overactivity is closely associated with vascular remodeling. Sympathetic fibers dominantly innervate the adventitia of arteries rather than tunica media. Vascular adventitial fibroblasts (VAFs) play crucial roles in vascular remodeling. However, the link between sympathetic o...

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Bibliographic Details
Main Authors: Yi-Ming Wang, Hong-Ke Dong, Min Dai, Jing-Xiao Wang, Xiao-Yu Xu, Guo-Qing Zhu, Xiu-Zhen Li
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Redox Report
Subjects:
Norepinephrine
vascular adventitial fibroblasts
oxidative stress
NADPH oxidase
hypertension
proliferation
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2025.2494314
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