A partial differential equation model of metastasized prostatic cancer
Biochemically failing metastatic prostate cancer is typically treated with androgen ablation. However, due to the emergence of castration-resistant cells that can survive in low androgen concentrations, such therapy eventually fails. Here, we develop a partial differential equation model of the grow...
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| Format: | Article |
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AIMS Press
2013-03-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.591 |
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| author | Avner Friedman Harsh Vardhan Jain |
| author_facet | Avner Friedman Harsh Vardhan Jain |
| author_sort | Avner Friedman |
| collection | DOAJ |
| description | Biochemically failing metastatic prostate cancer is typically treated with androgen ablation. However, due to the emergence of castration-resistant cells that can survive in low androgen concentrations, such therapy eventually fails. Here, we develop a partial differential equation model of the growth and response to treatment of prostate cancer that has metastasized to the bone. Existence and uniqueness results are derived for the resulting free boundary problem. In particular, existence and uniqueness of solutions for all time are proven for the radially symmetric case. Finally, numerical simulations of a tumor growing in 2-dimensions with radial symmetry are carried in order to evaluate the therapeutic potential of different treatment strategies. These simulations are able to reproduce a variety of clinically observed responses to treatment, and suggest treatment strategies that may result in tumor remission, underscoring our model's potential to make a significant contribution in the field of prostate cancer therapeutics. |
| format | Article |
| id | doaj-art-fadc7957f6794c1581cdca946148f9ea |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-fadc7957f6794c1581cdca946148f9ea2025-01-24T02:26:12ZengAIMS PressMathematical Biosciences and Engineering1551-00182013-03-0110359160810.3934/mbe.2013.10.591A partial differential equation model of metastasized prostatic cancerAvner Friedman0Harsh Vardhan Jain1Department of Mathematics, Ohio State University, Columbus, OH 43210Department of Mathematics, Ohio State University, Columbus, OH 43210Biochemically failing metastatic prostate cancer is typically treated with androgen ablation. However, due to the emergence of castration-resistant cells that can survive in low androgen concentrations, such therapy eventually fails. Here, we develop a partial differential equation model of the growth and response to treatment of prostate cancer that has metastasized to the bone. Existence and uniqueness results are derived for the resulting free boundary problem. In particular, existence and uniqueness of solutions for all time are proven for the radially symmetric case. Finally, numerical simulations of a tumor growing in 2-dimensions with radial symmetry are carried in order to evaluate the therapeutic potential of different treatment strategies. These simulations are able to reproduce a variety of clinically observed responses to treatment, and suggest treatment strategies that may result in tumor remission, underscoring our model's potential to make a significant contribution in the field of prostate cancer therapeutics.https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.591prostate cancerandrogen ablationmathematical modelpsa.free boundary problem |
| spellingShingle | Avner Friedman Harsh Vardhan Jain A partial differential equation model of metastasized prostatic cancer Mathematical Biosciences and Engineering prostate cancer androgen ablation mathematical model psa. free boundary problem |
| title | A partial differential equation model of metastasized prostatic cancer |
| title_full | A partial differential equation model of metastasized prostatic cancer |
| title_fullStr | A partial differential equation model of metastasized prostatic cancer |
| title_full_unstemmed | A partial differential equation model of metastasized prostatic cancer |
| title_short | A partial differential equation model of metastasized prostatic cancer |
| title_sort | partial differential equation model of metastasized prostatic cancer |
| topic | prostate cancer androgen ablation mathematical model psa. free boundary problem |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.591 |
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