David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma
Angiosarcoma (AS) is a rare and aggressive disease originating from blood or lymphatic vessel endothelium, representing <1% of soft-tissue sarcomas. The prognosis is generally poor, with a 5-year survival rate of only 30%–50%. The recurrence rate is high, and metastasis occurs in about half of th...
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Journal of Cancer Research and Practice |
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| Online Access: | https://journals.lww.com/10.4103/ejcrp.eJCRP-D-23-00033 |
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| author | Te-Lin Hsu San-Chi Chen |
| author_facet | Te-Lin Hsu San-Chi Chen |
| author_sort | Te-Lin Hsu |
| collection | DOAJ |
| description | Angiosarcoma (AS) is a rare and aggressive disease originating from blood or lymphatic vessel endothelium, representing <1% of soft-tissue sarcomas. The prognosis is generally poor, with a 5-year survival rate of only 30%–50%. The recurrence rate is high, and metastasis occurs in about half of the cases. The National Comprehensive Cancer Network guidelines recommend anthracycline-based, gemcitabine-based, and paclitaxel regimens as preferred first-line treatments for metastatic AS. Vinorelbine, a vinca alkaloid, is listed as supportive care in AS for patients unsuitable for intensive chemotherapy or who are heavily treated. Although the efficacy of vinorelbine is modest, some studies suggest its synergistic effect with immunotherapy. In our case report, a patient with metastatic AS received frontline paclitaxel followed by pembrolizumab, but this treatment failed. However, a complete response (CR) was achieved after oral vinorelbine. Remarkably, the patient remains in CR for 4.5 years after discontinuing vinorelbine. |
| format | Article |
| id | doaj-art-fad8ff3ab5f14306b467ec8ea1914b4d |
| institution | Kabale University |
| issn | 2311-3006 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cancer Research and Practice |
| spelling | doaj-art-fad8ff3ab5f14306b467ec8ea1914b4d2025-01-23T05:11:30ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062024-01-01111535510.4103/ejcrp.eJCRP-D-23-00033David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger AngiosarcomaTe-Lin HsuSan-Chi ChenAngiosarcoma (AS) is a rare and aggressive disease originating from blood or lymphatic vessel endothelium, representing <1% of soft-tissue sarcomas. The prognosis is generally poor, with a 5-year survival rate of only 30%–50%. The recurrence rate is high, and metastasis occurs in about half of the cases. The National Comprehensive Cancer Network guidelines recommend anthracycline-based, gemcitabine-based, and paclitaxel regimens as preferred first-line treatments for metastatic AS. Vinorelbine, a vinca alkaloid, is listed as supportive care in AS for patients unsuitable for intensive chemotherapy or who are heavily treated. Although the efficacy of vinorelbine is modest, some studies suggest its synergistic effect with immunotherapy. In our case report, a patient with metastatic AS received frontline paclitaxel followed by pembrolizumab, but this treatment failed. However, a complete response (CR) was achieved after oral vinorelbine. Remarkably, the patient remains in CR for 4.5 years after discontinuing vinorelbine.https://journals.lww.com/10.4103/ejcrp.eJCRP-D-23-00033angiosarcomachemotherapycomplete responseimmune checkpoint inhibitorvinorelbine |
| spellingShingle | Te-Lin Hsu San-Chi Chen David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma Journal of Cancer Research and Practice angiosarcoma chemotherapy complete response immune checkpoint inhibitor vinorelbine |
| title | David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma |
| title_full | David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma |
| title_fullStr | David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma |
| title_full_unstemmed | David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma |
| title_short | David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma |
| title_sort | david slays goliath exceptional efficacy of oral vinorelbine in conquering metastatic finger angiosarcoma |
| topic | angiosarcoma chemotherapy complete response immune checkpoint inhibitor vinorelbine |
| url | https://journals.lww.com/10.4103/ejcrp.eJCRP-D-23-00033 |
| work_keys_str_mv | AT telinhsu davidslaysgoliathexceptionalefficacyoforalvinorelbineinconqueringmetastaticfingerangiosarcoma AT sanchichen davidslaysgoliathexceptionalefficacyoforalvinorelbineinconqueringmetastaticfingerangiosarcoma |