Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System
The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clin...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2012/509783 |
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| _version_ | 1832563396992565248 |
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| author | Roberto Reif Jia Qin Lin An Zhongwei Zhi Suzan Dziennis Ruikang Wang |
| author_facet | Roberto Reif Jia Qin Lin An Zhongwei Zhi Suzan Dziennis Ruikang Wang |
| author_sort | Roberto Reif |
| collection | DOAJ |
| description | The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained with a spectral domain optical coherence tomography system. A technique for determining three measureable parameters (the fractal dimension, the vessel length fraction, and the vessel area density) is proposed and validated. Finally, the repeatability for acquiring OMAG images is determined, and a new method for analyzing small areas from these images is proposed. |
| format | Article |
| id | doaj-art-fac7b25c46a840b8937dbb0b7217ee87 |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-fac7b25c46a840b8937dbb0b7217ee872025-02-03T01:20:22ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962012-01-01201210.1155/2012/509783509783Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography SystemRoberto Reif0Jia Qin1Lin An2Zhongwei Zhi3Suzan Dziennis4Ruikang Wang5Department of Bioengineering, University of Washington, Seattle, WA 98195, USADepartment of Bioengineering, University of Washington, Seattle, WA 98195, USADepartment of Bioengineering, University of Washington, Seattle, WA 98195, USADepartment of Bioengineering, University of Washington, Seattle, WA 98195, USADepartment of Bioengineering, University of Washington, Seattle, WA 98195, USADepartment of Bioengineering, University of Washington, Seattle, WA 98195, USAThe blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained with a spectral domain optical coherence tomography system. A technique for determining three measureable parameters (the fractal dimension, the vessel length fraction, and the vessel area density) is proposed and validated. Finally, the repeatability for acquiring OMAG images is determined, and a new method for analyzing small areas from these images is proposed.http://dx.doi.org/10.1155/2012/509783 |
| spellingShingle | Roberto Reif Jia Qin Lin An Zhongwei Zhi Suzan Dziennis Ruikang Wang Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System International Journal of Biomedical Imaging |
| title | Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System |
| title_full | Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System |
| title_fullStr | Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System |
| title_full_unstemmed | Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System |
| title_short | Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System |
| title_sort | quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system |
| url | http://dx.doi.org/10.1155/2012/509783 |
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