Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene...

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Main Authors: Yulia N. Nosova, Ilia V. Zenin, Varvara P. Maximova, Ekaterina M. Zhidkova, Kirill I. Kirsanov, Ekaterina A. Lesovaya, Anna A. Lobas, Mikhail V. Gorshkov, Olga N. Kovaleva, Elena R. Milaeva, Markus Galanski, Bernhard K. Keppler, Alexey A. Nazarov
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2017/4736321
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