Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2017/4736321 |
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| author | Yulia N. Nosova Ilia V. Zenin Varvara P. Maximova Ekaterina M. Zhidkova Kirill I. Kirsanov Ekaterina A. Lesovaya Anna A. Lobas Mikhail V. Gorshkov Olga N. Kovaleva Elena R. Milaeva Markus Galanski Bernhard K. Keppler Alexey A. Nazarov |
| author_facet | Yulia N. Nosova Ilia V. Zenin Varvara P. Maximova Ekaterina M. Zhidkova Kirill I. Kirsanov Ekaterina A. Lesovaya Anna A. Lobas Mikhail V. Gorshkov Olga N. Kovaleva Elena R. Milaeva Markus Galanski Bernhard K. Keppler Alexey A. Nazarov |
| author_sort | Yulia N. Nosova |
| collection | DOAJ |
| description | We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive. |
| format | Article |
| id | doaj-art-fac7554cf940430381aa68a387731c73 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-fac7554cf940430381aa68a387731c732025-02-03T01:12:23ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2017-01-01201710.1155/2017/47363214736321Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of OxaliplatinYulia N. Nosova0Ilia V. Zenin1Varvara P. Maximova2Ekaterina M. Zhidkova3Kirill I. Kirsanov4Ekaterina A. Lesovaya5Anna A. Lobas6Mikhail V. Gorshkov7Olga N. Kovaleva8Elena R. Milaeva9Markus Galanski10Bernhard K. Keppler11Alexey A. Nazarov12Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, RussiaDepartment of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, RussiaBlokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, RussiaBlokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, RussiaBlokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, RussiaBlokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, RussiaInstitute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninsky Pr. 38, Bld.2, Moscow 119334, RussiaInstitute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninsky Pr. 38, Bld.2, Moscow 119334, RussiaI.M. Sechenov First Moscow State Medical University, Moscow, RussiaDepartment of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, RussiaFaculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1019 Vienna, AustriaFaculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1019 Vienna, AustriaDepartment of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, RussiaWe present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.http://dx.doi.org/10.1155/2017/4736321 |
| spellingShingle | Yulia N. Nosova Ilia V. Zenin Varvara P. Maximova Ekaterina M. Zhidkova Kirill I. Kirsanov Ekaterina A. Lesovaya Anna A. Lobas Mikhail V. Gorshkov Olga N. Kovaleva Elena R. Milaeva Markus Galanski Bernhard K. Keppler Alexey A. Nazarov Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin Bioinorganic Chemistry and Applications |
| title | Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin |
| title_full | Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin |
| title_fullStr | Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin |
| title_full_unstemmed | Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin |
| title_short | Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin |
| title_sort | influence of the number of axial bexarotene ligands on the cytotoxicity of pt iv analogs of oxaliplatin |
| url | http://dx.doi.org/10.1155/2017/4736321 |
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