Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4+ T cells during blood-stage Plasmodium infection.

Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4+ T cells during blood-stage Plasmodium infection.

Plasmodium-specific CD4+ T cells differentiate into effector and memory subsets during experimental malaria, via mechanisms that remain incompletely characterised. By mining scRNA-seq data of CD4+ T cells during Plasmodium chabaudi chabaudi AS infection in mice, we identified two genes previously un...

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Bibliographic Details
Main Authors: Takahiro Asatsuma, Marcela L Moreira, Hyun J Lee, Brooke J Wanrooy, Oliver P Skinner, Shihan Li, Ivana Rea, Taidhgin Harkin, Saba Asad, Cameron G Williams, Lynette Beattie, Ashraful Haque
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0320375
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