Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland
Number of tick-borne encephalitis (TBE) cases has increased and new foci have emerged in Finland during the last decade. We evaluated risk for locally acquired TBE in the capital region inhabited by 1.2 million people. We screened ticks and small mammals from probable places of TBE virus (TBEV) tran...
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| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1612279 |
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| author | Teemu Smura Elina Tonteri Anu Jääskeläinen Gabriel von Troil Suvi Kuivanen Otso Huitu Lauri Kareinen Joni Uusitalo Ruut Uusitalo Tuula Hannila-Handelberg Liina Voutilainen Simo Nikkari Tarja Sironen Jussi Sane Janne Castrén Olli Vapalahti |
| author_facet | Teemu Smura Elina Tonteri Anu Jääskeläinen Gabriel von Troil Suvi Kuivanen Otso Huitu Lauri Kareinen Joni Uusitalo Ruut Uusitalo Tuula Hannila-Handelberg Liina Voutilainen Simo Nikkari Tarja Sironen Jussi Sane Janne Castrén Olli Vapalahti |
| author_sort | Teemu Smura |
| collection | DOAJ |
| description | Number of tick-borne encephalitis (TBE) cases has increased and new foci have emerged in Finland during the last decade. We evaluated risk for locally acquired TBE in the capital region inhabited by 1.2 million people. We screened ticks and small mammals from probable places of TBE virus (TBEV) transmission and places without reported circulation. The TBEV positive samples were sequenced and subjected to phylogenetic analysis. Within the study period 2007–2017, there was a clear increase of both all TBE cases and locally acquired cases in the Helsinki area. The surveillance of ticks and small mammals for TBEV confirmed four distinct TBEV foci in the Helsinki area. All detected TBEV strains were of the European subtype. TBEV genome sequences indicated that distinct TBEV lineages circulate in each focus. Molecular clock analysis suggested that the virus lineages were introduced to these foci decades ago. In conclusion, TBE has emerged in the mainland of Helsinki area during the last decade, with at least four distinct virus lineages independently introduced into the region previously. Although the overall annual TBE incidence is below the threshold for recommending general vaccinations, the situation requires further surveillance to detect and prevent possible further emergence of local TBE clusters. |
| format | Article |
| id | doaj-art-faba366454a6494db5e99d844016436e |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-faba366454a6494db5e99d844016436e2025-08-20T03:17:54ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-018167568310.1080/22221751.2019.1612279Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, FinlandTeemu Smura0Elina Tonteri1Anu Jääskeläinen2Gabriel von Troil3Suvi Kuivanen4Otso Huitu5Lauri Kareinen6Joni Uusitalo7Ruut Uusitalo8Tuula Hannila-Handelberg9Liina Voutilainen10Simo Nikkari11Tarja Sironen12Jussi Sane13Janne Castrén14Olli Vapalahti15Department of Virology, University of Helsinki, Helsinki, FinlandCenters for Military Medicine and Biothreat Preparedness, Helsinki, FinlandDivision of Clinical Microbiology, Helsinki University Hospital Laboratory Services (HUSLAB), Helsinki, FinlandArchipelago Doctors Ltd, Parainen, FinlandDepartment of Virology, University of Helsinki, Helsinki, FinlandNatural Resources Institute Finland (Luke), Helsinki, FinlandDepartment of Virology, University of Helsinki, Helsinki, FinlandDepartment of Virology, University of Helsinki, Helsinki, FinlandDepartment of Virology, University of Helsinki, Helsinki, FinlandCenters for Military Medicine and Biothreat Preparedness, Helsinki, FinlandCenters for Military Medicine and Biothreat Preparedness, Helsinki, FinlandCenters for Military Medicine and Biothreat Preparedness, Helsinki, FinlandDepartment of Virology, University of Helsinki, Helsinki, FinlandDepartment of Health Security, Infectious Disease Control and Vaccinations Unit, National Institute for Health and Welfare, Helsinki, FinlandArchipelago Doctors Ltd, Parainen, FinlandDepartment of Virology, University of Helsinki, Helsinki, FinlandNumber of tick-borne encephalitis (TBE) cases has increased and new foci have emerged in Finland during the last decade. We evaluated risk for locally acquired TBE in the capital region inhabited by 1.2 million people. We screened ticks and small mammals from probable places of TBE virus (TBEV) transmission and places without reported circulation. The TBEV positive samples were sequenced and subjected to phylogenetic analysis. Within the study period 2007–2017, there was a clear increase of both all TBE cases and locally acquired cases in the Helsinki area. The surveillance of ticks and small mammals for TBEV confirmed four distinct TBEV foci in the Helsinki area. All detected TBEV strains were of the European subtype. TBEV genome sequences indicated that distinct TBEV lineages circulate in each focus. Molecular clock analysis suggested that the virus lineages were introduced to these foci decades ago. In conclusion, TBE has emerged in the mainland of Helsinki area during the last decade, with at least four distinct virus lineages independently introduced into the region previously. Although the overall annual TBE incidence is below the threshold for recommending general vaccinations, the situation requires further surveillance to detect and prevent possible further emergence of local TBE clusters.https://www.tandfonline.com/doi/10.1080/22221751.2019.1612279Tick-borne encephalitisflavivirusincidencephylogenyFinland |
| spellingShingle | Teemu Smura Elina Tonteri Anu Jääskeläinen Gabriel von Troil Suvi Kuivanen Otso Huitu Lauri Kareinen Joni Uusitalo Ruut Uusitalo Tuula Hannila-Handelberg Liina Voutilainen Simo Nikkari Tarja Sironen Jussi Sane Janne Castrén Olli Vapalahti Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland Emerging Microbes and Infections Tick-borne encephalitis flavivirus incidence phylogeny Finland |
| title | Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland |
| title_full | Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland |
| title_fullStr | Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland |
| title_full_unstemmed | Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland |
| title_short | Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland |
| title_sort | recent establishment of tick borne encephalitis foci with distinct viral lineages in the helsinki area finland |
| topic | Tick-borne encephalitis flavivirus incidence phylogeny Finland |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1612279 |
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