Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement
Periodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties. They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM). Various studies have applied controlled mechanical...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/6531216 |
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| author | Huaming Huang Ruili Yang Yan-heng Zhou |
| author_facet | Huaming Huang Ruili Yang Yan-heng Zhou |
| author_sort | Huaming Huang |
| collection | DOAJ |
| description | Periodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties. They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM). Various studies have applied controlled mechanical stimulation to PDLSCs and investigated the effects of orthodontic force on PDLSCs. Physical stimuli can regulate the proliferation and differentiation of PDLSCs. During the past decade, a variety of studies has demonstrated that applied forces can activate different signaling pathways in PDLSCs, including MAPK, TGF-β/Smad, and Wnt/β-catenin pathways. Besides, recent advances have highlighted the critical role of orthodontic force in PDLSC fate through mediators, such as IL-11, CTHRC1, miR-21, and H2S. This perspective review critically discusses the PDLSC fate to physical force in vitro and orthodontic force in vivo, as well as the underlying molecular mechanism involved in OTM. |
| format | Article |
| id | doaj-art-fab755bf30cc46b68892f70272a2d7bd |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-fab755bf30cc46b68892f70272a2d7bd2025-08-20T02:22:37ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/65312166531216Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth MovementHuaming Huang0Ruili Yang1Yan-heng Zhou2Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaPeriodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties. They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM). Various studies have applied controlled mechanical stimulation to PDLSCs and investigated the effects of orthodontic force on PDLSCs. Physical stimuli can regulate the proliferation and differentiation of PDLSCs. During the past decade, a variety of studies has demonstrated that applied forces can activate different signaling pathways in PDLSCs, including MAPK, TGF-β/Smad, and Wnt/β-catenin pathways. Besides, recent advances have highlighted the critical role of orthodontic force in PDLSC fate through mediators, such as IL-11, CTHRC1, miR-21, and H2S. This perspective review critically discusses the PDLSC fate to physical force in vitro and orthodontic force in vivo, as well as the underlying molecular mechanism involved in OTM.http://dx.doi.org/10.1155/2018/6531216 |
| spellingShingle | Huaming Huang Ruili Yang Yan-heng Zhou Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement Stem Cells International |
| title | Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement |
| title_full | Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement |
| title_fullStr | Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement |
| title_full_unstemmed | Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement |
| title_short | Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement |
| title_sort | mechanobiology of periodontal ligament stem cells in orthodontic tooth movement |
| url | http://dx.doi.org/10.1155/2018/6531216 |
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