Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders
Abstract Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. Yes-associated protein 1 (YAP)/ WW domain-containing transcription regulator 1 (TAZ) serves as a pivotal transcripti...
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| Format: | Article |
| Language: | English |
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BMC
2024-10-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-04011-9 |
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| author | Juanjuan Han Jiale Zhang Xiaoyi Zhang Wenxin Luo Lifei Liu Yuqing Zhu Qingfeng Liu Xin-an Zhang |
| author_facet | Juanjuan Han Jiale Zhang Xiaoyi Zhang Wenxin Luo Lifei Liu Yuqing Zhu Qingfeng Liu Xin-an Zhang |
| author_sort | Juanjuan Han |
| collection | DOAJ |
| description | Abstract Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. Yes-associated protein 1 (YAP)/ WW domain-containing transcription regulator 1 (TAZ) serves as a pivotal transcription factor within the Hippo signaling pathway, which undergoes negative regulation by the Hippo pathway. The expression of YAP/TAZ affects various biological processes, including differentiation of osteoblasts (OB) and osteoclasts (OC), cartilage homeostasis, skeletal muscle development, regeneration and quality maintenance. At the same time, the dysregulation of the Hippo pathway can concurrently contribute to the development of various musculoskeletal disorders, including bone tumors, osteoporosis (OP), osteoarthritis (OA), intervertebral disc degeneration (IDD), muscular dystrophy, and rhabdomyosarcoma (RMS). Therefore, targeting the Hippo pathway has emerged as a promising therapeutic strategy for the treatment of musculoskeletal disorders. The focus of this review is to elucidate the mechanisms by which the Hippo pathway maintains homeostasis in bone, cartilage, and skeletal muscle, while also providing a comprehensive summary of the pivotal role played by core components of this pathway in musculoskeletal diseases. The efficacy and feasibility of Hippo pathway-related drugs for targeted therapy of musculoskeletal diseases are also discussed in our study. These endeavors offer novel insights into the application of Hippo signaling in musculoskeletal disorders, providing effective therapeutic targets and potential drug candidates for treating such conditions. |
| format | Article |
| id | doaj-art-fab4ac2379974eeda29bbc0a8a44a16b |
| institution | OA Journals |
| issn | 1757-6512 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-fab4ac2379974eeda29bbc0a8a44a16b2025-08-20T02:18:20ZengBMCStem Cell Research & Therapy1757-65122024-10-0115111810.1186/s13287-024-04011-9Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disordersJuanjuan Han0Jiale Zhang1Xiaoyi Zhang2Wenxin Luo3Lifei Liu4Yuqing Zhu5Qingfeng Liu6Xin-an Zhang7College of Exercise and Health, Shenyang Sport UniversityCollege of Exercise and Health, Shenyang Sport UniversityCollege of Second Clinical Medical, China Medical UniversityCollege of Exercise and Health, Shenyang Sport UniversityDepartment of Rehabilitation, The People’s Hospital of Liaoning ProvinceCollege of Exercise and Health, Shenyang Sport UniversityDepartment of General Surgery, Jinqiu Hospital of Liaoning ProvinceCollege of Exercise and Health, Shenyang Sport UniversityAbstract Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. Yes-associated protein 1 (YAP)/ WW domain-containing transcription regulator 1 (TAZ) serves as a pivotal transcription factor within the Hippo signaling pathway, which undergoes negative regulation by the Hippo pathway. The expression of YAP/TAZ affects various biological processes, including differentiation of osteoblasts (OB) and osteoclasts (OC), cartilage homeostasis, skeletal muscle development, regeneration and quality maintenance. At the same time, the dysregulation of the Hippo pathway can concurrently contribute to the development of various musculoskeletal disorders, including bone tumors, osteoporosis (OP), osteoarthritis (OA), intervertebral disc degeneration (IDD), muscular dystrophy, and rhabdomyosarcoma (RMS). Therefore, targeting the Hippo pathway has emerged as a promising therapeutic strategy for the treatment of musculoskeletal disorders. The focus of this review is to elucidate the mechanisms by which the Hippo pathway maintains homeostasis in bone, cartilage, and skeletal muscle, while also providing a comprehensive summary of the pivotal role played by core components of this pathway in musculoskeletal diseases. The efficacy and feasibility of Hippo pathway-related drugs for targeted therapy of musculoskeletal diseases are also discussed in our study. These endeavors offer novel insights into the application of Hippo signaling in musculoskeletal disorders, providing effective therapeutic targets and potential drug candidates for treating such conditions.https://doi.org/10.1186/s13287-024-04011-9HippoYAP/TAZMusculoskeletal diseasesOsteoblastOsteoclastCartilage |
| spellingShingle | Juanjuan Han Jiale Zhang Xiaoyi Zhang Wenxin Luo Lifei Liu Yuqing Zhu Qingfeng Liu Xin-an Zhang Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders Stem Cell Research & Therapy Hippo YAP/TAZ Musculoskeletal diseases Osteoblast Osteoclast Cartilage |
| title | Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders |
| title_full | Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders |
| title_fullStr | Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders |
| title_full_unstemmed | Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders |
| title_short | Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders |
| title_sort | emerging role and function of hippo yap taz signaling pathway in musculoskeletal disorders |
| topic | Hippo YAP/TAZ Musculoskeletal diseases Osteoblast Osteoclast Cartilage |
| url | https://doi.org/10.1186/s13287-024-04011-9 |
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