In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss method following intravenous admini...

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Bibliographic Details
Main Authors: Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Animal Models and Experimental Medicine
Subjects:
acute toxicity
blood pressure
haloperidol
hemolysis
LD50
target prediction
Online Access:https://doi.org/10.1002/ame2.12531
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