Multimodal spatial proteomic profiling in acute myeloid leukemia

Multimodal spatial proteomic profiling in acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) resides in an immune-rich microenvironment, yet, immune-based therapies have faltered in eliciting durable responses. Bridging this paradox requires a comprehensive understanding of leukemic interactions within the bone marrow microenvironment. We optimized a hi...

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Main Authors: Christopher P. Ly, Ivo Veletic, Christopher D. Pacheco, Enes Dasdemir, Fatima Z. Jelloul, Sammy Ferri-Borgogno, Akshay V. Basi, Javier A. Gomez, Jessica L. Root, Patrick K. Reville, Sonali Jindal, Sreyashi Basu, Padmanee Sharma, Andres E. Quesada, Carlos Bueso-Ramos, Taghi Manshouri, Branko Cuglievan, Miriam Garcia, Jared K. Burks, Hussein A. Abbas
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00897-7
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