Maternal blood lead level and its impact on cord blood hematological parameters
Introduction. More than 13 annual million deaths are caused by environmental pollutants worldwide. Urbanization, population growth, industrialization and globalization affect our lives both positively and negatively. Women can become lead exposed through occupational and environmental sources. Once...
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2024-05-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1998 |
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| author | N. T. Gorgadze Ju. Yu. Ungiadze L. T. Akhvlediani D. D. Ungiadze V. O. Baziari Kh. N. Lomauri N. Zh. Kokaia M. Sh. Giorgobiani |
| author_facet | N. T. Gorgadze Ju. Yu. Ungiadze L. T. Akhvlediani D. D. Ungiadze V. O. Baziari Kh. N. Lomauri N. Zh. Kokaia M. Sh. Giorgobiani |
| author_sort | N. T. Gorgadze |
| collection | DOAJ |
| description | Introduction. More than 13 annual million deaths are caused by environmental pollutants worldwide. Urbanization, population growth, industrialization and globalization affect our lives both positively and negatively. Women can become lead exposed through occupational and environmental sources. Once lead enters the body, it is mainly deposited in diverse organs: brain, kidneys, liver and bones. The body stores lead mainly in the bones, where it accumulates over time that may be further released into the bloodstream during pregnancy, thus posing a threat to growing fetus. Aim: to examine a lead impact on newborn hematological parameters during perinatal period. Materials and Methods. A retrospective cohort study with 306 pregnant women and paired newborns was carried out. Peripheral blood lead level (BLL) in pregnant and postpartum women was analyzed by using the atomic-absorption spectrophotometry method. Blood specimens were collected for analysis in the third trimester of pregnancy. Newborns hemoglobin concentration (mean corpuscular hemoglobin concentration, MCHC) in erythrocytes was also assessed. Results. We have detected a statistically significant decrease of MCHC in babies born to mothers with BLL > 0.24 µmol/L vs. BLL < 0.24 µmol/L. This difference may indicate a decline in hemoglobin fetal production caused by lead intoxication. Conclusion. Study corroborates an idea that pregnant women with occupational or environmental lead exposure should be monitored for BLL, which should not exceed 0.24 µmol/L during pregnancy. |
| format | Article |
| id | doaj-art-fa96afa85a8b4f22a9ded7fd7334874c |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2024-05-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-fa96afa85a8b4f22a9ded7fd7334874c2025-08-20T02:53:55ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942024-05-0118221121710.17749/2313-7347/ob.gyn.rep.2024.496873Maternal blood lead level and its impact on cord blood hematological parametersN. T. Gorgadze0Ju. Yu. Ungiadze1L. T. Akhvlediani2D. D. Ungiadze3V. O. Baziari4Kh. N. Lomauri5N. Zh. Kokaia6M. Sh. Giorgobiani7David Agmashenebeli University of Georgia; Iris Borchashvili Health Center ''Medina''Iris Borchashvili Health Center ''Medina''; Shota Rustaveli Batumi State UniversityShota Rustaveli Batumi State University; BAU International University BatumiBAU International University Batumi; Petre Shotadze Tbilisi Medical AcademyTbilisi State Medical UniversityTbilisi State Medical UniversityPetre Shotadze Tbilisi Medical AcademyDavid Agmashenebeli University of GeorgiaIntroduction. More than 13 annual million deaths are caused by environmental pollutants worldwide. Urbanization, population growth, industrialization and globalization affect our lives both positively and negatively. Women can become lead exposed through occupational and environmental sources. Once lead enters the body, it is mainly deposited in diverse organs: brain, kidneys, liver and bones. The body stores lead mainly in the bones, where it accumulates over time that may be further released into the bloodstream during pregnancy, thus posing a threat to growing fetus. Aim: to examine a lead impact on newborn hematological parameters during perinatal period. Materials and Methods. A retrospective cohort study with 306 pregnant women and paired newborns was carried out. Peripheral blood lead level (BLL) in pregnant and postpartum women was analyzed by using the atomic-absorption spectrophotometry method. Blood specimens were collected for analysis in the third trimester of pregnancy. Newborns hemoglobin concentration (mean corpuscular hemoglobin concentration, MCHC) in erythrocytes was also assessed. Results. We have detected a statistically significant decrease of MCHC in babies born to mothers with BLL > 0.24 µmol/L vs. BLL < 0.24 µmol/L. This difference may indicate a decline in hemoglobin fetal production caused by lead intoxication. Conclusion. Study corroborates an idea that pregnant women with occupational or environmental lead exposure should be monitored for BLL, which should not exceed 0.24 µmol/L during pregnancy.https://www.gynecology.su/jour/article/view/1998lead exposureumbilical bloodhematological parametersmean corpuscular hemoglobin concentrationmchc |
| spellingShingle | N. T. Gorgadze Ju. Yu. Ungiadze L. T. Akhvlediani D. D. Ungiadze V. O. Baziari Kh. N. Lomauri N. Zh. Kokaia M. Sh. Giorgobiani Maternal blood lead level and its impact on cord blood hematological parameters Акушерство, гинекология и репродукция lead exposure umbilical blood hematological parameters mean corpuscular hemoglobin concentration mchc |
| title | Maternal blood lead level and its impact on cord blood hematological parameters |
| title_full | Maternal blood lead level and its impact on cord blood hematological parameters |
| title_fullStr | Maternal blood lead level and its impact on cord blood hematological parameters |
| title_full_unstemmed | Maternal blood lead level and its impact on cord blood hematological parameters |
| title_short | Maternal blood lead level and its impact on cord blood hematological parameters |
| title_sort | maternal blood lead level and its impact on cord blood hematological parameters |
| topic | lead exposure umbilical blood hematological parameters mean corpuscular hemoglobin concentration mchc |
| url | https://www.gynecology.su/jour/article/view/1998 |
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