Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary c...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/497387 |
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| _version_ | 1850162228299300864 |
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| author | Monica Sala-Rabanal Zeynep Yurtsever Kayla N. Berry Tom J. Brett |
| author_facet | Monica Sala-Rabanal Zeynep Yurtsever Kayla N. Berry Tom J. Brett |
| author_sort | Monica Sala-Rabanal |
| collection | DOAJ |
| description | Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases. |
| format | Article |
| id | doaj-art-fa9552dc30a24306a78b2190c0095dbe |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fa9552dc30a24306a78b2190c0095dbe2025-08-20T02:22:37ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/497387497387Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway DiseasesMonica Sala-Rabanal0Zeynep Yurtsever1Kayla N. Berry2Tom J. Brett3Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USACenter for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USAChloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.http://dx.doi.org/10.1155/2015/497387 |
| spellingShingle | Monica Sala-Rabanal Zeynep Yurtsever Kayla N. Berry Tom J. Brett Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases Mediators of Inflammation |
| title | Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases |
| title_full | Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases |
| title_fullStr | Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases |
| title_full_unstemmed | Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases |
| title_short | Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases |
| title_sort | novel roles for chloride channels exchangers and regulators in chronic inflammatory airway diseases |
| url | http://dx.doi.org/10.1155/2015/497387 |
| work_keys_str_mv | AT monicasalarabanal novelrolesforchloridechannelsexchangersandregulatorsinchronicinflammatoryairwaydiseases AT zeynepyurtsever novelrolesforchloridechannelsexchangersandregulatorsinchronicinflammatoryairwaydiseases AT kaylanberry novelrolesforchloridechannelsexchangersandregulatorsinchronicinflammatoryairwaydiseases AT tomjbrett novelrolesforchloridechannelsexchangersandregulatorsinchronicinflammatoryairwaydiseases |