Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma
Objective: To evaluate the relation between solar elastosis and tumor mutation burden (TMB) in a large clinically annotated cohort of stage II and III melanoma patients. Methods: Primary cutaneous melanomas from 469 AJCC (8th edition) stage II and III patients with clinical annotation including outc...
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Elsevier
2024-12-01
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| Series: | EJC Skin Cancer |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772611824002623 |
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| author | Cecilia Lezcano Li Luo Ronglai Shen Irene Orlow Nancy E. Thomas Marianne Berwick Klaus J. Busam |
| author_facet | Cecilia Lezcano Li Luo Ronglai Shen Irene Orlow Nancy E. Thomas Marianne Berwick Klaus J. Busam |
| author_sort | Cecilia Lezcano |
| collection | DOAJ |
| description | Objective: To evaluate the relation between solar elastosis and tumor mutation burden (TMB) in a large clinically annotated cohort of stage II and III melanoma patients. Methods: Primary cutaneous melanomas from 469 AJCC (8th edition) stage II and III patients with clinical annotation including outcome at 5 years of diagnosis were histopathologically evaluated for solar elastosis. Next-generation sequencing assay MSK-IMPACTTM was employed to determine TMB. Analysis by Fisher’s exact test, chi-square, and Kruskal-Wallis were performed, as well as uni- and multivariate logistic regression. Results: Tumors stratified by low and high TMB showed marked and statistically significant differences in presence and extent of associated solar elastosis. Lower risk patient stage (II versus III by AJCC 8th edition) as well as better 5-year melanomaspecific survival (as binary variable of controls-survivors versus cases-dead of disease at 5 years of diagnosis) were associated with severe solar elastosis. On univariate and multivariate logistic regression models, severe solar elastosis predicted significantly decreased odds of dying of melanoma within 5 years of diagnosis (OR 0.60, 95 % CI 0.39–0.89; and OR 0.42, 95 % CI 0.20–0.83, respectively; both p<0.05) Conclusion: The association of solar elastosis to TMB and 5-year melanoma specific survival points to its potential as a biomarker of clinical relevance that can be assessed by routine histopathology. |
| format | Article |
| id | doaj-art-fa9184bccc8b4c7fbdb383182b3fc673 |
| institution | DOAJ |
| issn | 2772-6118 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EJC Skin Cancer |
| spelling | doaj-art-fa9184bccc8b4c7fbdb383182b3fc6732025-08-20T02:50:09ZengElsevierEJC Skin Cancer2772-61182024-12-01210027410.1016/j.ejcskn.2024.100274Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanomaCecilia Lezcano0Li Luo1Ronglai Shen2Irene Orlow3Nancy E. Thomas4Marianne Berwick5Klaus J. Busam6Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Correspondence to: Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.Department of Internal Medicine and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USADepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Dermatology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USADepartment of Internal Medicine and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USADepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USAObjective: To evaluate the relation between solar elastosis and tumor mutation burden (TMB) in a large clinically annotated cohort of stage II and III melanoma patients. Methods: Primary cutaneous melanomas from 469 AJCC (8th edition) stage II and III patients with clinical annotation including outcome at 5 years of diagnosis were histopathologically evaluated for solar elastosis. Next-generation sequencing assay MSK-IMPACTTM was employed to determine TMB. Analysis by Fisher’s exact test, chi-square, and Kruskal-Wallis were performed, as well as uni- and multivariate logistic regression. Results: Tumors stratified by low and high TMB showed marked and statistically significant differences in presence and extent of associated solar elastosis. Lower risk patient stage (II versus III by AJCC 8th edition) as well as better 5-year melanomaspecific survival (as binary variable of controls-survivors versus cases-dead of disease at 5 years of diagnosis) were associated with severe solar elastosis. On univariate and multivariate logistic regression models, severe solar elastosis predicted significantly decreased odds of dying of melanoma within 5 years of diagnosis (OR 0.60, 95 % CI 0.39–0.89; and OR 0.42, 95 % CI 0.20–0.83, respectively; both p<0.05) Conclusion: The association of solar elastosis to TMB and 5-year melanoma specific survival points to its potential as a biomarker of clinical relevance that can be assessed by routine histopathology.http://www.sciencedirect.com/science/article/pii/S2772611824002623MelanomaSolar elastosisTumor mutation burden |
| spellingShingle | Cecilia Lezcano Li Luo Ronglai Shen Irene Orlow Nancy E. Thomas Marianne Berwick Klaus J. Busam Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma EJC Skin Cancer Melanoma Solar elastosis Tumor mutation burden |
| title | Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma |
| title_full | Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma |
| title_fullStr | Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma |
| title_full_unstemmed | Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma |
| title_short | Solar elastosis correlates with high tumor mutation burden and better 5-year disease-specific survival in patients with stage II/III melanoma |
| title_sort | solar elastosis correlates with high tumor mutation burden and better 5 year disease specific survival in patients with stage ii iii melanoma |
| topic | Melanoma Solar elastosis Tumor mutation burden |
| url | http://www.sciencedirect.com/science/article/pii/S2772611824002623 |
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