Enhanced rational protein engineering to reduce viscosity in high-concentration IgG1 antibody solutions

Subcutaneous (SC) delivery of therapeutic antibodies can offer multiple benefits to patients and healthcare providers, including convenience, time savings, and cost reduction. To improve the SC injection experience, drug developers may seek a low injection volume (1–2 mL), which for some antibody dr...

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Bibliographic Details
Main Authors: Tyler J. Lefevre, Jenna G. Caldwell, Austin Gallegos, Qun Du, Erin Houston, Gilad Kaplan, Reza Esfandiary
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2543771
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