Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis
ABSTRACT: Background: Chronic pain after breast cancer surgery, affecting 25%-60% of patients, significantly impacts the survivors’ quality of life. With improved survival rates, more individuals are experiencing this long-term complication. It is often overlooked that this chronic pain may stem fr...
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Elsevier
2024-12-01
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| Series: | JPRAS Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352587824001219 |
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| author | Esmee Kwee Lucas G. de Groot Paula Rijs Alonso Keghart Krikour Liron S. Duraku Caroline A. Hundepool J. Michiel Zuidam |
| author_facet | Esmee Kwee Lucas G. de Groot Paula Rijs Alonso Keghart Krikour Liron S. Duraku Caroline A. Hundepool J. Michiel Zuidam |
| author_sort | Esmee Kwee |
| collection | DOAJ |
| description | ABSTRACT: Background: Chronic pain after breast cancer surgery, affecting 25%-60% of patients, significantly impacts the survivors’ quality of life. With improved survival rates, more individuals are experiencing this long-term complication. It is often overlooked that this chronic pain may stem from peripheral nerve injury, resulting in neuropathic pain characterized by burning sensations, electric shocks, and heightened sensitivity. Although neuropathic pain prevalence is reported at 24%-36% post-mastectomy, the data following breast-conserving surgery remain limited. This systematic review aimed to investigate the prevalence of neuropathic pain after breast-conserving surgery and its potential association with axillary procedures. Methods: The electronic databases, Medline, Embase, Web of Science and Cochrane Central, were searched. Inclusion criteria were defined to include studies reporting on the prevalence of neuropathic pain following breast-conserving surgery and exploring associations with axillary procedures. A meta-analysis was performed to compute a pooled prevalence rate. Results: Eight studies, covering 1,469 patients post-breast-conserving surgery, met the inclusion criteria. The meta-analysis revealed a pooled prevalence of 31% (95% confidence intervals [CI] 0.14-0.56) neuropathic pain among patients who underwent breast-conserving surgery. Six studies explored associations with axillary procedures; however, none suggested a correlation between axillary procedures and neuropathic pain after breast-conserving surgery. Conclusion: This systematic review and meta-analysis indicated a pooled prevalence of 31% neuropathic pain following breast-conserving surgery of, with confidence interval ranging from 14% to 56%. The review did not provide conclusive evidence to suggest correlations between axillary procedures and neuropathic pain after breast-conserving surgery. |
| format | Article |
| id | doaj-art-fa89238e979a43acbd3445cea159fd56 |
| institution | OA Journals |
| issn | 2352-5878 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JPRAS Open |
| spelling | doaj-art-fa89238e979a43acbd3445cea159fd562025-08-20T02:21:03ZengElsevierJPRAS Open2352-58782024-12-0142485710.1016/j.jpra.2024.07.021Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-AnalysisEsmee Kwee0Lucas G. de Groot1Paula Rijs Alonso2Keghart Krikour3Liron S. Duraku4Caroline A. Hundepool5J. Michiel Zuidam6Department of Plastic, Reconstructive Surgery and Hand surgery, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Plastic, Reconstructive Surgery and Hand surgery, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Plastic, Reconstructive Surgery and Hand surgery, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Plastic, Reconstructive Surgery and Hand surgery, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Plastic, Reconstructive Surgery and Hand surgery, Amsterdam University Medical Center, Amsterdam, The NetherlandsDepartment of Plastic, Reconstructive Surgery and Hand surgery, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Plastic, Reconstructive Surgery and Hand surgery, Erasmus Medical Center, Rotterdam, The Netherlands; Corresponding author: J. Michiel Zuidam, M.D., Ph.D., Department of Plastic, Reconstructive Surgery, and Hand surgery Erasmus Medical Center University Medical Center Rotterdam P.O. Box 2040 3000 CA Rotterdam, The NetherlandsABSTRACT: Background: Chronic pain after breast cancer surgery, affecting 25%-60% of patients, significantly impacts the survivors’ quality of life. With improved survival rates, more individuals are experiencing this long-term complication. It is often overlooked that this chronic pain may stem from peripheral nerve injury, resulting in neuropathic pain characterized by burning sensations, electric shocks, and heightened sensitivity. Although neuropathic pain prevalence is reported at 24%-36% post-mastectomy, the data following breast-conserving surgery remain limited. This systematic review aimed to investigate the prevalence of neuropathic pain after breast-conserving surgery and its potential association with axillary procedures. Methods: The electronic databases, Medline, Embase, Web of Science and Cochrane Central, were searched. Inclusion criteria were defined to include studies reporting on the prevalence of neuropathic pain following breast-conserving surgery and exploring associations with axillary procedures. A meta-analysis was performed to compute a pooled prevalence rate. Results: Eight studies, covering 1,469 patients post-breast-conserving surgery, met the inclusion criteria. The meta-analysis revealed a pooled prevalence of 31% (95% confidence intervals [CI] 0.14-0.56) neuropathic pain among patients who underwent breast-conserving surgery. Six studies explored associations with axillary procedures; however, none suggested a correlation between axillary procedures and neuropathic pain after breast-conserving surgery. Conclusion: This systematic review and meta-analysis indicated a pooled prevalence of 31% neuropathic pain following breast-conserving surgery of, with confidence interval ranging from 14% to 56%. The review did not provide conclusive evidence to suggest correlations between axillary procedures and neuropathic pain after breast-conserving surgery.http://www.sciencedirect.com/science/article/pii/S2352587824001219Breast cancer surgeryBreast-conserving surgeryLumpectomyChronic painNeuropathic pain |
| spellingShingle | Esmee Kwee Lucas G. de Groot Paula Rijs Alonso Keghart Krikour Liron S. Duraku Caroline A. Hundepool J. Michiel Zuidam Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis JPRAS Open Breast cancer surgery Breast-conserving surgery Lumpectomy Chronic pain Neuropathic pain |
| title | Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis |
| title_full | Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis |
| title_fullStr | Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis |
| title_short | Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis |
| title_sort | neuropathic pain following breast conserving surgery a systematic review and meta analysis |
| topic | Breast cancer surgery Breast-conserving surgery Lumpectomy Chronic pain Neuropathic pain |
| url | http://www.sciencedirect.com/science/article/pii/S2352587824001219 |
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