Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation
Purpose: To explore the effect of defocus region and amount, diurnal rhythm, and accommodation on myopic defocus-induced changes in the retina and choroid. Design: Four test lenses were used: single-vision soft contact lens (SVCL), bifocal spectacle lens (BSL) with +3.50 diopters (D) addition in the...
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Elsevier
2025-09-01
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| Series: | Ophthalmology Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914525000715 |
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| author | Yingying Huang, MD Jiali Zhang, MD Xue Li, PhD Hao Chen, MD, OD Jinhua Bao, PhD |
| author_facet | Yingying Huang, MD Jiali Zhang, MD Xue Li, PhD Hao Chen, MD, OD Jinhua Bao, PhD |
| author_sort | Yingying Huang, MD |
| collection | DOAJ |
| description | Purpose: To explore the effect of defocus region and amount, diurnal rhythm, and accommodation on myopic defocus-induced changes in the retina and choroid. Design: Four test lenses were used: single-vision soft contact lens (SVCL), bifocal spectacle lens (BSL) with +3.50 diopters (D) addition in the inferior visual field, defocus incorporated multiple segments lens (DIMS), and dual-focus contact lens (DFCL) with +2.00 D addition. Participants: Twenty-one adults aged between 18 and 30 years, myopia between −1.00 D and −6.00 D, were included. Methods: Four lenses were used in random order at 4 separate days for each participant. Participants underwent OCT and OCT angiography examinations after distance-viewing (4 m) and near-viewing (20 cm) for 20 minutes with 4 test lenses at both 10 am and 5 pm. Main Outcome Measures: Retinal and choroidal thicknesses (RT and ChT) and vessel density were assessed. Results: The changes in RT, retinal and choroidal vessel density were not significantly different between lenses or times (all P > 0.05). Choroidal thickness changes differed between lenses after near-viewing in both the morning and evening and after distance-viewing in the morning (all P < 0.05). Compared with SVCL, BSL, DIMS, and DFCL achieved lower ChT reductions (all P < 0.05), and BSL showed least reduction. No lenses completely inhibited ChT thinning after near-viewing. Conclusions: Myopic defocus inhibited choroid thinning more effectively in the morning, and provided sufficient defocus in the superior retina was more effective. The amount of lens defocus in this study (+3.50 D) was insufficient to inhibit choroidal thinning with 5 D accommodation completely. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
| format | Article |
| id | doaj-art-fa868f6d5df14af5adc0cead6f1cd91c |
| institution | DOAJ |
| issn | 2666-9145 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj-art-fa868f6d5df14af5adc0cead6f1cd91c2025-08-20T03:14:02ZengElsevierOphthalmology Science2666-91452025-09-015510077310.1016/j.xops.2025.100773Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and AccommodationYingying Huang, MD0Jiali Zhang, MD1Xue Li, PhD2Hao Chen, MD, OD3Jinhua Bao, PhD4National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaCorrespondence: Jinhua Bao, PhD, Eye Hospital of Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, Zhejiang, China, 325027.; National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaPurpose: To explore the effect of defocus region and amount, diurnal rhythm, and accommodation on myopic defocus-induced changes in the retina and choroid. Design: Four test lenses were used: single-vision soft contact lens (SVCL), bifocal spectacle lens (BSL) with +3.50 diopters (D) addition in the inferior visual field, defocus incorporated multiple segments lens (DIMS), and dual-focus contact lens (DFCL) with +2.00 D addition. Participants: Twenty-one adults aged between 18 and 30 years, myopia between −1.00 D and −6.00 D, were included. Methods: Four lenses were used in random order at 4 separate days for each participant. Participants underwent OCT and OCT angiography examinations after distance-viewing (4 m) and near-viewing (20 cm) for 20 minutes with 4 test lenses at both 10 am and 5 pm. Main Outcome Measures: Retinal and choroidal thicknesses (RT and ChT) and vessel density were assessed. Results: The changes in RT, retinal and choroidal vessel density were not significantly different between lenses or times (all P > 0.05). Choroidal thickness changes differed between lenses after near-viewing in both the morning and evening and after distance-viewing in the morning (all P < 0.05). Compared with SVCL, BSL, DIMS, and DFCL achieved lower ChT reductions (all P < 0.05), and BSL showed least reduction. No lenses completely inhibited ChT thinning after near-viewing. Conclusions: Myopic defocus inhibited choroid thinning more effectively in the morning, and provided sufficient defocus in the superior retina was more effective. The amount of lens defocus in this study (+3.50 D) was insufficient to inhibit choroidal thinning with 5 D accommodation completely. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.http://www.sciencedirect.com/science/article/pii/S2666914525000715Myopic defocusChoroidAccommodationDiurnal rhythm |
| spellingShingle | Yingying Huang, MD Jiali Zhang, MD Xue Li, PhD Hao Chen, MD, OD Jinhua Bao, PhD Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation Ophthalmology Science Myopic defocus Choroid Accommodation Diurnal rhythm |
| title | Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation |
| title_full | Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation |
| title_fullStr | Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation |
| title_full_unstemmed | Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation |
| title_short | Effect of Myopic Defocus on the Retina and Choroid and Its Interaction with Defocus Regions, Diurnal Rhythm, and Accommodation |
| title_sort | effect of myopic defocus on the retina and choroid and its interaction with defocus regions diurnal rhythm and accommodation |
| topic | Myopic defocus Choroid Accommodation Diurnal rhythm |
| url | http://www.sciencedirect.com/science/article/pii/S2666914525000715 |
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