Innovative CDR grafting and computational methods for PD-1 specific nanobody design

Innovative CDR grafting and computational methods for PD-1 specific nanobody design

IntroductionThe development of nanobodies targeting Programmed Cell Death Protein-1 (PD-1) offers a promising approach in cancer immunotherapy. This study aims to design and characterize a PD-1-specific nanobody using an integrated computational and experimental approach.MethodsAn in silico design s...

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Bibliographic Details
Main Authors: Jagadeeswara Reddy Devasani, Girijasankar Guntuku, Nalini Panatula, Murali Krishna Kumar Muthyala, Mary Sulakshana Palla, Teruna J. Siahaan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Bioinformatics
Subjects:
cancer immunotherapy
nanobody
programmed cell death protein-1
complementarity-determining region
Western blot
ELISA
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2024.1488331/full
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