Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout
Tophaceous gout is a crystal arthropathy and a disorder of purine metabolism characterized by monosodium urate crystal deposition. A case of tophaceous gout of the knee joint in a 30-year-old female is reported, and the imaging appearances on high-resolution ultrasonography are described. The patien...
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Knowledge E
2021-10-01
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| Series: | Dubai Medical Journal |
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| author | Ravikanth Reddy |
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| author_sort | Ravikanth Reddy |
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| description | Tophaceous gout is a crystal arthropathy and a disorder of purine metabolism characterized by monosodium urate crystal deposition. A case of tophaceous gout of the knee joint in a 30-year-old female is reported, and the imaging appearances on high-resolution ultrasonography are described. The patient presented with complaints of insidious onset painless swelling of the left knee joint with limitation of range of movement for 1 week. The aspirated joint fluid demonstrated needle-like monosodium urate crystals showing strong negative birefringence consistent with a diagnosis of tophaceous gout. Targeted urate-lowering treatment included oral nonsteroidal anti-inflammatory drugs and oral colchicine. Prophylactic treatment for gout flare-ups included initiation of allopurinol at 300 mg/day along with modification of the dietary regimen including limited consumption of red meat and increased consumption of low-fat dairy products. Symptomatic improvement with reduced pain and swelling of the knee joint was noted at 10 days after treatment. Subsequently, at 3-month follow-up, the patient was disease free with no signs of recurrence and serum uric acid levels at 3.7 mg/dL. In spite of a wide range of therapeutic options available for the management of tophaceous gout, suboptimal management of gout is prevalent till date in both developing and developed nations across the world. |
| format | Article |
| id | doaj-art-fa7de4b6aad541078197d0dbc768b2b2 |
| institution | DOAJ |
| issn | 2571-726X |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Knowledge E |
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| spelling | doaj-art-fa7de4b6aad541078197d0dbc768b2b22025-08-20T02:43:55ZengKnowledge EDubai Medical Journal2571-726X2021-10-011510.1159/000519571519571Monoarticular Crystal Arthropathy of the Knee: Tophaceous GoutRavikanth Reddyhttps://orcid.org/0000-0003-0879-6181Tophaceous gout is a crystal arthropathy and a disorder of purine metabolism characterized by monosodium urate crystal deposition. A case of tophaceous gout of the knee joint in a 30-year-old female is reported, and the imaging appearances on high-resolution ultrasonography are described. The patient presented with complaints of insidious onset painless swelling of the left knee joint with limitation of range of movement for 1 week. The aspirated joint fluid demonstrated needle-like monosodium urate crystals showing strong negative birefringence consistent with a diagnosis of tophaceous gout. Targeted urate-lowering treatment included oral nonsteroidal anti-inflammatory drugs and oral colchicine. Prophylactic treatment for gout flare-ups included initiation of allopurinol at 300 mg/day along with modification of the dietary regimen including limited consumption of red meat and increased consumption of low-fat dairy products. Symptomatic improvement with reduced pain and swelling of the knee joint was noted at 10 days after treatment. Subsequently, at 3-month follow-up, the patient was disease free with no signs of recurrence and serum uric acid levels at 3.7 mg/dL. In spite of a wide range of therapeutic options available for the management of tophaceous gout, suboptimal management of gout is prevalent till date in both developing and developed nations across the world.https://www.karger.com/Article/FullText/519571tophaceous goutfemale patienthigh-resolution ultrasonographyknee jointmonosodium urate crystals |
| spellingShingle | Ravikanth Reddy Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout Dubai Medical Journal tophaceous gout female patient high-resolution ultrasonography knee joint monosodium urate crystals |
| title | Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout |
| title_full | Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout |
| title_fullStr | Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout |
| title_full_unstemmed | Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout |
| title_short | Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout |
| title_sort | monoarticular crystal arthropathy of the knee tophaceous gout |
| topic | tophaceous gout female patient high-resolution ultrasonography knee joint monosodium urate crystals |
| url | https://www.karger.com/Article/FullText/519571 |
| work_keys_str_mv | AT ravikanthreddy monoarticularcrystalarthropathyofthekneetophaceousgout |