Diversity of Epithelial Stem Cell Types in Adult Lung
Lung is a complex organ lined with epithelial cells. In order to maintain its homeostasis and normal functions following injuries caused by varied extraneous and intraneous insults, such as inhaled environmental pollutants and overwhelming inflammatory responses, the respiratory epithelium normally...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/728307 |
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| author | Feng Li Jinxi He Jun Wei William C. Cho Xiaoming Liu |
| author_facet | Feng Li Jinxi He Jun Wei William C. Cho Xiaoming Liu |
| author_sort | Feng Li |
| collection | DOAJ |
| description | Lung is a complex organ lined with epithelial cells. In order to maintain its homeostasis and normal functions following injuries caused by varied extraneous and intraneous insults, such as inhaled environmental pollutants and overwhelming inflammatory responses, the respiratory epithelium normally undergoes regenerations by the proliferation and differentiation of region-specific epithelial stem/progenitor cells that resided in distinct niches along the airway tree. The importance of local epithelial stem cell niches in the specification of lung stem/progenitor cells has been recently identified. Studies using cell differentiating and lineage tracing assays, in vitro and/or ex vivo models, and genetically engineered mice have suggested that these local epithelial stem/progenitor cells within spatially distinct regions along the pulmonary tree contribute to the injury repair of epithelium adjacent to their respective niches. This paper reviews recent findings in the identification and isolation of region-specific epithelial stem/progenitor cells and local niches along the airway tree and the potential link of epithelial stem cells for the development of lung cancer. |
| format | Article |
| id | doaj-art-fa7b73c444c441258a63e0a721d74113 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-fa7b73c444c441258a63e0a721d741132025-02-03T01:31:07ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/728307728307Diversity of Epithelial Stem Cell Types in Adult LungFeng Li0Jinxi He1Jun Wei2William C. Cho3Xiaoming Liu4Center of Medical Laboratory of the General Hospital, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Thoracic Surgery of the General Hospital, Ningxia Medical University, Yinchuan 750004, ChinaCenter of Medical Laboratory of the General Hospital, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong KongCenter of Medical Laboratory of the General Hospital, Ningxia Medical University, Yinchuan 750004, ChinaLung is a complex organ lined with epithelial cells. In order to maintain its homeostasis and normal functions following injuries caused by varied extraneous and intraneous insults, such as inhaled environmental pollutants and overwhelming inflammatory responses, the respiratory epithelium normally undergoes regenerations by the proliferation and differentiation of region-specific epithelial stem/progenitor cells that resided in distinct niches along the airway tree. The importance of local epithelial stem cell niches in the specification of lung stem/progenitor cells has been recently identified. Studies using cell differentiating and lineage tracing assays, in vitro and/or ex vivo models, and genetically engineered mice have suggested that these local epithelial stem/progenitor cells within spatially distinct regions along the pulmonary tree contribute to the injury repair of epithelium adjacent to their respective niches. This paper reviews recent findings in the identification and isolation of region-specific epithelial stem/progenitor cells and local niches along the airway tree and the potential link of epithelial stem cells for the development of lung cancer.http://dx.doi.org/10.1155/2015/728307 |
| spellingShingle | Feng Li Jinxi He Jun Wei William C. Cho Xiaoming Liu Diversity of Epithelial Stem Cell Types in Adult Lung Stem Cells International |
| title | Diversity of Epithelial Stem Cell Types in Adult Lung |
| title_full | Diversity of Epithelial Stem Cell Types in Adult Lung |
| title_fullStr | Diversity of Epithelial Stem Cell Types in Adult Lung |
| title_full_unstemmed | Diversity of Epithelial Stem Cell Types in Adult Lung |
| title_short | Diversity of Epithelial Stem Cell Types in Adult Lung |
| title_sort | diversity of epithelial stem cell types in adult lung |
| url | http://dx.doi.org/10.1155/2015/728307 |
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