Topical application of the HSP90 inhibitor 17-AAG reduces skin inflammation and partially restores microbial balance: implications for atopic dermatitis therapy

Topical application of the HSP90 inhibitor 17-AAG reduces skin inflammation and partially restores microbial balance: implications for atopic dermatitis therapy

Abstract Heat shock proteins belonging to the HSP90 family promote inflammation and are potential therapeutic targets in inflammatory and autoimmune diseases. Here the effects of the HSP90 inhibitor 17-AAG applied topically were evaluated in a DNCB-induced murine model of atopic dermatitis (AD). The...

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Bibliographic Details
Main Authors: Krzysztof Sitko, Ewa Piotrowska, Magdalena Podlacha, Natalia Zagórska, Michał D. Starke, Magdalena Trzeciak, Stefan Tukaj
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Heat shock proteins
Mouse model
Microbiota
Staphylococcus aureus
Eosinophiles
Keratinocytes.
Online Access:https://doi.org/10.1038/s41598-025-05307-3
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