A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a Smartphone
Alpha-fetoprotein (AFP) is a key marker for early cancer detection and assessment. However, the current detection methods struggle to balance accuracy with the need for decentralized medical treatment. To address this issue, a new AFP analysis platform utilizing digital image colorimetry has been de...
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| Format: | Article |
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MDPI AG
2024-08-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/15/9/1116 |
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| author | Junjie Liu Qingfubo Geng Zhaoxin Geng |
| author_facet | Junjie Liu Qingfubo Geng Zhaoxin Geng |
| author_sort | Junjie Liu |
| collection | DOAJ |
| description | Alpha-fetoprotein (AFP) is a key marker for early cancer detection and assessment. However, the current detection methods struggle to balance accuracy with the need for decentralized medical treatment. To address this issue, a new AFP analysis platform utilizing digital image colorimetry has been developed. Functionalized gold nanoparticles act as colorimetric agents, changing from purple-red to light gray-blue when exposed to different AFP concentrations. A smartphone app captures these color changes and calculates the AFP concentration in the sample. To improve detection accuracy, a hardware device ensures uniform illumination. Testing has confirmed that this system can quantitatively analyze AFP using colorimetry. The limit of detection reached 0.083 ng/mL, and the average accuracy reached 90.81%. This innovative method enhances AFP testing by offering portability, precision, and low cost, making it particularly suitable for resource-limited areas. |
| format | Article |
| id | doaj-art-fa7189f694b74e75ba2cdf5b4848e08f |
| institution | OA Journals |
| issn | 2072-666X |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj-art-fa7189f694b74e75ba2cdf5b4848e08f2025-08-20T01:55:41ZengMDPI AGMicromachines2072-666X2024-08-01159111610.3390/mi15091116A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a SmartphoneJunjie Liu0Qingfubo Geng1Zhaoxin Geng2School of Information Engineering, Minzu University of China, Beijing 100081, ChinaSchool of Information Engineering, Minzu University of China, Beijing 100081, ChinaSchool of Information Engineering, Minzu University of China, Beijing 100081, ChinaAlpha-fetoprotein (AFP) is a key marker for early cancer detection and assessment. However, the current detection methods struggle to balance accuracy with the need for decentralized medical treatment. To address this issue, a new AFP analysis platform utilizing digital image colorimetry has been developed. Functionalized gold nanoparticles act as colorimetric agents, changing from purple-red to light gray-blue when exposed to different AFP concentrations. A smartphone app captures these color changes and calculates the AFP concentration in the sample. To improve detection accuracy, a hardware device ensures uniform illumination. Testing has confirmed that this system can quantitatively analyze AFP using colorimetry. The limit of detection reached 0.083 ng/mL, and the average accuracy reached 90.81%. This innovative method enhances AFP testing by offering portability, precision, and low cost, making it particularly suitable for resource-limited areas.https://www.mdpi.com/2072-666X/15/9/1116biosensorcolorimetric detectionmicrofluidics |
| spellingShingle | Junjie Liu Qingfubo Geng Zhaoxin Geng A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a Smartphone Micromachines biosensor colorimetric detection microfluidics |
| title | A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a Smartphone |
| title_full | A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a Smartphone |
| title_fullStr | A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a Smartphone |
| title_full_unstemmed | A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a Smartphone |
| title_short | A Route to the Colorimetric Detection of Alpha-Fetoprotein Based on a Smartphone |
| title_sort | route to the colorimetric detection of alpha fetoprotein based on a smartphone |
| topic | biosensor colorimetric detection microfluidics |
| url | https://www.mdpi.com/2072-666X/15/9/1116 |
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