Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | Cancer Communications |
| Online Access: | https://doi.org/10.1002/cac2.70015 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849418737265934336 |
|---|---|
| author | Florian Henning Geyer Alina Ritter Seneca Kinn‐Gurzo Tobias Faehling Jing Li Armin Jarosch Carine Ngo Endrit Vinca Karim Aljakouch Azhar Orynbek Shunya Ohmura Thomas Kirchner Roland Imle Laura Romero‐Pérez Juan Díaz‐Martín Stefanie Bertram Enrique deÁlava Clémence Henon Sophie Postel‐Vilnay Ana Banito Martin Sill Yvonne Versleijen‐Jonkers Benjamin Friedrich Berthold Mayer Martin Ebinger Monika Sparber‐Sauer Sabine Stegmaier Daniel Baumhoer Wolfgang Hartmann Jeroen Krijgsveld David Horst Olivier Delattre Patrick Joseph Grohar Thomas Georg Phillip Grünewald Florencia Cidre‐Aranaz |
| author_facet | Florian Henning Geyer Alina Ritter Seneca Kinn‐Gurzo Tobias Faehling Jing Li Armin Jarosch Carine Ngo Endrit Vinca Karim Aljakouch Azhar Orynbek Shunya Ohmura Thomas Kirchner Roland Imle Laura Romero‐Pérez Juan Díaz‐Martín Stefanie Bertram Enrique deÁlava Clémence Henon Sophie Postel‐Vilnay Ana Banito Martin Sill Yvonne Versleijen‐Jonkers Benjamin Friedrich Berthold Mayer Martin Ebinger Monika Sparber‐Sauer Sabine Stegmaier Daniel Baumhoer Wolfgang Hartmann Jeroen Krijgsveld David Horst Olivier Delattre Patrick Joseph Grohar Thomas Georg Phillip Grünewald Florencia Cidre‐Aranaz |
| author_sort | Florian Henning Geyer |
| collection | DOAJ |
| format | Article |
| id | doaj-art-fa70c06ff8c744ef96329b7083f4b407 |
| institution | Kabale University |
| issn | 2523-3548 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj-art-fa70c06ff8c744ef96329b7083f4b4072025-08-20T03:32:22ZengWileyCancer Communications2523-35482025-06-0145670270810.1002/cac2.70015Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature geneFlorian Henning Geyer0Alina Ritter1Seneca Kinn‐Gurzo2Tobias Faehling3Jing Li4Armin Jarosch5Carine Ngo6Endrit Vinca7Karim Aljakouch8Azhar Orynbek9Shunya Ohmura10Thomas Kirchner11Roland Imle12Laura Romero‐Pérez13Juan Díaz‐Martín14Stefanie Bertram15Enrique deÁlava16Clémence Henon17Sophie Postel‐Vilnay18Ana Banito19Martin Sill20Yvonne Versleijen‐Jonkers21Benjamin Friedrich Berthold Mayer22Martin Ebinger23Monika Sparber‐Sauer24Sabine Stegmaier25Daniel Baumhoer26Wolfgang Hartmann27Jeroen Krijgsveld28David Horst29Olivier Delattre30Patrick Joseph Grohar31Thomas Georg Phillip Grünewald32Florencia Cidre‐Aranaz33Hopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyChildren's Hospital of Philadelphia Philadelphia Pennsylvania USAHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyDepartment of Pathology Charité‐University Medicine Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐University of Berlin Berlin GermanySarcoma Unit, Gustave Roussy Cancer Campus Villejuif FranceHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyDivision of Proteomics of Stem Cells and Cancer German Cancer Research Center (DKFZ), and Heidelberg University Medical Faculty Heidelberg GermanyDivision of Proteomics of Stem Cells and Cancer German Cancer Research Center (DKFZ), and Heidelberg University Medical Faculty Heidelberg GermanyHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyInstitute of Pathology, Faculty of Medicine, Ludwig‐Maximilian‐University of Munich Munich GermanyHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyInstitute of Biomedicine of Seville (IBiS)/University Hospital Virgen del Rocío/CSIC/University of Seville/CIBERONC Seville SpainInstitute of Biomedicine of Seville (IBiS)/University Hospital Virgen del Rocío/CSIC/University of Seville/CIBERONC Seville SpainInstitute of Pathology, University Hospital Essen Essen GermanyInstitute of Biomedicine of Seville (IBiS)/University Hospital Virgen del Rocío/CSIC/University of Seville/CIBERONC Seville SpainERC Chromatin Remodeling, DNA Repair, and Epigenetics Laboratory, ARC Team for Fundamental Research, INSERM U981, and Drug Development Department Gustave Roussy Villejuif FranceERC Chromatin Remodeling, DNA Repair, and Epigenetics Laboratory, ARC Team for Fundamental Research, INSERM U981, and Drug Development Department Gustave Roussy Villejuif FranceHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyDepartment of Medical Oncology Radboud University Medical Center Nijmegen The NetherlandsDepartment of Pediatric Surgery and Pediatric Urology University Children's Hospital Tübingen GermanyDepartment of Pediatric Hematology and Oncology University Children's Hospital Tuebingen GermanyStuttgart University Hospital gKAöR, Olgahospital, Stuttgart Cancer Center, Center for Child, Adolescent, and Women's Medicine, Pediatrics 5 (Pediatric Oncology, Hematology, Immunology) Stuttgart GermanyStuttgart University Hospital gKAöR, Olgahospital, Stuttgart Cancer Center, Center for Child, Adolescent, and Women's Medicine, Pediatrics 5 (Pediatric Oncology, Hematology, Immunology) Stuttgart GermanyBone Tumor Reference Centre, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, and Basel Research Centre of Child Health Basel SwitzerlandGerhard‐Domagk‐Institute of Pathology, University of Muenster Muenster GermanyDivision of Proteomics of Stem Cells and Cancer German Cancer Research Center (DKFZ), and Heidelberg University Medical Faculty Heidelberg GermanyDepartment of Pathology Charité‐University Medicine Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐University of Berlin Berlin GermanyDiversity and Plasticity of Pediatric Tumors, Paris Sciences and Letters University, SIREDO Oncology Centre, Institut Curie Paris FranceChildren's Hospital of Philadelphia Philadelphia Pennsylvania USAHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg GermanyHopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg Germanyhttps://doi.org/10.1002/cac2.70015 |
| spellingShingle | Florian Henning Geyer Alina Ritter Seneca Kinn‐Gurzo Tobias Faehling Jing Li Armin Jarosch Carine Ngo Endrit Vinca Karim Aljakouch Azhar Orynbek Shunya Ohmura Thomas Kirchner Roland Imle Laura Romero‐Pérez Juan Díaz‐Martín Stefanie Bertram Enrique deÁlava Clémence Henon Sophie Postel‐Vilnay Ana Banito Martin Sill Yvonne Versleijen‐Jonkers Benjamin Friedrich Berthold Mayer Martin Ebinger Monika Sparber‐Sauer Sabine Stegmaier Daniel Baumhoer Wolfgang Hartmann Jeroen Krijgsveld David Horst Olivier Delattre Patrick Joseph Grohar Thomas Georg Phillip Grünewald Florencia Cidre‐Aranaz Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene Cancer Communications |
| title | Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene |
| title_full | Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene |
| title_fullStr | Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene |
| title_full_unstemmed | Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene |
| title_short | Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene |
| title_sort | comprehensive dsrct multi omics analyses unveil cacna2d2 as a diagnostic hallmark and super enhancer driven ewsr1 wt1 signature gene |
| url | https://doi.org/10.1002/cac2.70015 |
| work_keys_str_mv | AT florianhenninggeyer comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT alinaritter comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT senecakinngurzo comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT tobiasfaehling comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT jingli comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT arminjarosch comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT carinengo comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT endritvinca comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT karimaljakouch comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT azharorynbek comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT shunyaohmura comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT thomaskirchner comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT rolandimle comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT lauraromeroperez comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT juandiazmartin comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT stefaniebertram comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT enriquedealava comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT clemencehenon comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT sophiepostelvilnay comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT anabanito comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT martinsill comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT yvonneversleijenjonkers comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT benjaminfriedrichbertholdmayer comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT martinebinger comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT monikasparbersauer comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT sabinestegmaier comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT danielbaumhoer comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT wolfganghartmann comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT jeroenkrijgsveld comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT davidhorst comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT olivierdelattre comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT patrickjosephgrohar comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT thomasgeorgphillipgrunewald comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene AT florenciacidrearanaz comprehensivedsrctmultiomicsanalysesunveilcacna2d2asadiagnostichallmarkandsuperenhancerdrivenewsr1wt1signaturegene |