Ultra-rapid lispro or fast-acting aspart compared to standard insulin lispro and aspart using closed-loop insulin therapy: a systematic review and meta-analysis of randomized control trials

Ultra-rapid lispro or fast-acting aspart compared to standard insulin lispro and aspart using closed-loop insulin therapy: a systematic review and meta-analysis of randomized control trials

BackgroundUltra-rapid-acting insulin (URAI) improves glycemic control by reducing variability; however, optimal strategies for its use, especially within hybrid closed-loop (HCL) insulin delivery systems, remain unclear. This meta-analysis assesses the efficacy and safety of combining URAI with HCL...

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Main Authors: Mohamed Saad Rakab, Rahma Mogahed Rateb, Basel Hatem Elsalakawi, Bashar M. Al Zoubi, Abubakar Nazir, Mutaz Moath Abu-Laila, Abdelrahman Sherif Ghanem, Alaa Maamoun, Mohab Mattar, Basma Ataallah, Brian T. Layden, Abeer M. Mahmoud
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
closed-loop systems
ultra fast acting insulin analogs
type 1 diabetes
glucose variability
meta-analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1600157/full
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