Synthesis, structure and properties of N-R-2-(5-(5-methyl-1H-pyrazole-3-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetamides

Synthesis, structure and properties of N-R-2-(5-(5-methyl-1H-pyrazole-3-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetamides

Heterocyclic compounds remain the most promising group of compounds, through which the new drugs with characteristic list of properties are successfully created. Examples of this systems are 1,2,4-triazole and pyrazole. The presence in one molecule structure of fragments of two different azaheterocy...

Full description

Saved in:

Bibliographic Details
Main Authors:	A. S. Hotsulia, S. O. Fedotov
Format:	Article
Language:	English
Published:	Zaporizhzhia State Medical and Pharmaceutical University 2019-03-01
Series:	Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:	1 2 4-triazole pyrazole physical-chemical properties molecular docking
Online Access:	http://pharmed.zsmu.edu.ua/article/view/158913/158772
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis and properties of S-alkyl 4-amino-5-(5-(3-fluorophenyl)-pyrazol-3-yl)-1,2,4-triazole-3-thiol derivatives
by: S. O. Fedotov, et al.
Published: (2023-04-01)

Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol
by: S. O. Fedotov, et al.
Published: (2023-11-01)

Synthesis and properties of 6-(2,6-dichlorophenyl)-3- (3-methyl-1H-pyrazol-5-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazine-7-carboxylic acid and its salts
by: S. O. Fedotov, et al.
Published: (2023-07-01)

Synthesis and properties of some 3-(5-(4-methoxyphenyl)pyrazol-3-yl)-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles
by: S. O. Fedotov, et al.
Published: (2022-08-01)

Synthesis and properties of some S-derivatives of 4-phenyl-5-((5-phenylamino-1,3,4-thiadiazole-2-ylthio)methyl)-1,2,4-triazole-3-thione
by: A. S. Hotsulia, et al.
Published: (2019-12-01)

Synthesis and properties of 3-(ethylthio)-9-methyl-6-(alkylthio)pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines
by: S. O. Fedotov, et al.
Published: (2022-12-01)

Synthesis of New Heterocyclic Derivatives from 4-(3, 5-Dimethyl-1-phenyl-1H-pyrazol-4-ylazo)- benzoic acid
by: Baghdad Science Journal
Published: (2010-03-01)

2-([1,1′-Biphenyl]-4-yl)-5-[(<i>E</i>)-2-(3-methoxy-1-phenyl-1<i>H</i>-pyrazol-4-yl)ethenyl]-3,3-dimethyl-3<i>H</i>-indole
by: Gabrielė Varvuolytė, et al.
Published: (2024-11-01)

Synthesis and physical-chemical properties of 3-(4-(tert-butyl)phenyl)-5-(R-ylthio)-4H-1,2,4-triazol-4-amines
by: I. I. Aksyonova, et al.
Published: (2016-04-01)

Synthesis of N-(5-(Substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine from 4-Amino-4H-1,2,4-triazole
by: Ashvin D. Panchal, et al.
Published: (2011-01-01)

Synthesis and properties of 5-(((5-amino-1,3,4-thiadiazole-2-yl)thio)methyl)-4-phenyl-1,2,4-triazole-3-thione and its some S-derivatives
by: A. S. Hotsulia, et al.
Published: (2020-08-01)

Synthesis, biological evaluation, molecular docking, and DFT calculation of novel 4-(1H-indol-3-yl)-3-methyl-1-phenyl-1H-furo[2,3-c]pyrazole derivatives
by: Mahmoud Nassiri, et al.
Published: (2025-03-01)

Effect of 4-benzylidenamino-5-phenyl-4Н-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4Н-1,2,4-triazole-3-ylthio)acetic acid on central component of nociceptive system
by: Ye. S. Pruhlo
Published: (2016-08-01)

Synthesis and evaluation of the antifungal activity of 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide for use in the oral environment
by: Hossein Amin Zadeh, et al.
Published: (2024-03-01)

Synthesis, structure and properties of some 5-R-4-phenyl-1,2,4-triazole-3-thiol derivatives
by: A. S. Hotsulia
Published: (2019-12-01)

Synthesis and properties of 2-(4-phenyl-5-(((5-phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its salts
by: A. S. Hotsulia, et al.
Published: (2020-11-01)

Synthesis and properties of S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol
by: S. O. Fedotov, et al.
Published: (2021-12-01)

Synthesis and investigation of the physicochemical properties of 2-(5-((theophylline-7'-yl)methyl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)-acetic acid salts
by: A. S. Gotsulya, et al.
Published: (2014-02-01)

1-[(2-Bromophenyl)diphenylmethyl]-3-(trifluoromethyl)-1H-pyrazole–1-(triphenylmethyl)-3-(trifluoromethyl)-1H-pyrazole (0.638:0.362)
by: Firudin I. Guseinov, et al.
Published: (2025-06-01)

Antihypoxic activity of salts of (2-(5-(adamantane-1-yl)-4H-1,2,4-triazole-3-ylthio) acetate acids
by: V. M. Odintsova, et al.
Published: (2014-04-01)

4-phenyl-5-((pyrimidin-2-ylthio)methyl)-1,2,4-triazole-3-thiol as a platform for the synthesis of unsymmetrical disulfides
by: Yu. V. Karpenko, et al.
Published: (2025-03-01)

In silico study of biological activity of 2-[5-(furan-2-yl)-4-phenyl-4n-1,2,4-triazol-3-ylthio]-1-(4-chlorophenylethanone)
by: N. M. Borysenko, et al.
Published: (2025-06-01)

Synthesis and properties of some pyrazole derivatives of 1,2,4-triazole-3-thiol
by: A. S. Hotsulia, et al.
Published: (2020-11-01)

Preparation and Spectral Study of New Complexes of Some Metal Ions with 3,5-Dimethyl-1H-Pyrazol-1-yl Phenyl Methanone
by: Baghdad Science Journal
Published: (2011-12-01)

Synthesis, anticancer evaluation, and electrochemical investigation of new chiral pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides
by: Mateusz Kciuk, et al.
Published: (2025-05-01)

Synthesis, antimicrobial and antifungal activity of 3-(2-bromophenyl)-5-(alkylthio)-4-phenyl-4H-1,2,4-triazoles
by: A. A. Safonov, et al.
Published: (2022-12-01)

Mass-spectrometric fragmentation of sodium 2-(4-methyl-5-(thiophene-2-yl)-4H-1,2,4-triazole-3-ylthio)acetate
by: V. A. Salionov, et al.
Published: (2015-10-01)

<i>N</i>-(3-(<i>tert</i>-Butyl)-1-methyl-1<i>H</i>-pyrazol-5-yl)-4-methyl-<i>N</i>-tosylbenzenesulfonamide
by: Diana Becerra, et al.
Published: (2025-04-01)

The synthesis of 5-amino-3-aryl-1H-pyrazole-4-carbonitriles based on hydrazines and benzhydrazides under ultrasonic activation conditions
by: Meshcheryakova, Anna A., et al.
Published: (2024-09-01)

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines
by: Ye. O. Karpun, et al.
Published: (2020-11-01)

Synthesis and research of the physical-chemical properties of 5-((2-bromphenyl)-4-amino-4H-1,2,4-triazole-3-ylthio)acetic acid salts
by: Ye. S. Pruglo
Published: (2018-03-01)

Targeting Alzheimer's disease with novel dual-function 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives
by: Aikaterini Katsogiannou, et al.
Published: (2024-12-01)

The research of acute toxicity of 4-amino-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol derivatives
by: I. I. Аksyonova-Seliuk, et al.
Published: (2017-08-01)

In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives
by: Ye. O. Karpun, et al.
Published: (2019-12-01)

Actoprotective activity of 2-(4-r-3-(thiophen-2-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid
by: V. O. Salionov, et al.
Published: (2017-03-01)

Synthesis and Structural Insight into the Bioactivity of Imines with 1,5-Dimethyl-2-Phenyl-1H-Pyrazol-3(2H)-One Structural Unit Derived from Phenolic Aldehydes
by: Muamer Dizdar, et al.
Published: (2025-01-01)

Anti-inflammatory activity of 2-(5-((theophylline-7'-yl)methyl)-4-R-4H-1,2,4-triazole-3-ylthio)acetic acid salts
by: A. S. Gotsulya, et al.
Published: (2014-12-01)

Antioxidant activity of salts of 2-(5-R-4-amino-1,2,4-triazole-3-ylthio)acetic acid
by: Ye. S. Pruglo
Published: (2017-12-01)

Establishment of diuretic activity indicators for (3-thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols and their derivatives
by: A. M. Rud, et al.
Published: (2018-08-01)

Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts
by: A. S. Gotsulya
Published: (2016-04-01)