Genetics and Tumor Microenvironment of Renal Cell Carcinoma
Renal cell carcinoma is a diverse group of diseases that can be distinguished by distinct histopathologic and genomic features. In this comprehensive review, we highlight recent advancements in our understanding of the genetic and microenvironmental hallmarks of kidney cancer. We begin with clear...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Société Internationale d’Urologie Journal |
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| Online Access: | https://siuj.org/index.php/siuj/article/download/217/170 |
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| author | Sari Khaleel Christopher Ricketts W. Marston Linehan Mark Ball Brandon Manley Samra Turajilic James Brugarolas Ari Hakimi |
| author_facet | Sari Khaleel Christopher Ricketts W. Marston Linehan Mark Ball Brandon Manley Samra Turajilic James Brugarolas Ari Hakimi |
| author_sort | Sari Khaleel |
| collection | DOAJ |
| description | Renal cell carcinoma is a diverse group of diseases that can be distinguished by distinct histopathologic and genomic
features. In this comprehensive review, we highlight recent advancements in our understanding of the genetic and
microenvironmental hallmarks of kidney cancer. We begin with clear cell renal cell carcinoma (ccRCC), the most
common subtype of this disease. We review the chromosomal and genetic alterations that drive initiation and
progression of ccRCC, which has recently been shown to follow multiple highly conserved evolutionary trajectories
that in turn impact disease progression and prognosis. We also review the diverse genetic events that define the many
recently recognized rare subtypes within non-clear cell RCC. Finally, we discuss our evolving understanding of the
ccRCC microenvironment, which has been revolutionized by recent bulk and single-cell transcriptomic analyses,
suggesting potential biomarkers for guiding systemic therapy in the management of advanced ccRCC. |
| format | Article |
| id | doaj-art-fa6da6e015554c299dd8748de96a5f1f |
| institution | DOAJ |
| issn | 2563-6499 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Société Internationale d’Urologie Journal |
| spelling | doaj-art-fa6da6e015554c299dd8748de96a5f1f2025-08-20T03:20:04ZengMDPI AGSociété Internationale d’Urologie Journal2563-64992022-11-013638639610.48083/BLPV3411Genetics and Tumor Microenvironment of Renal Cell CarcinomaSari KhaleelChristopher RickettsW. Marston LinehanMark BallBrandon ManleySamra TurajilicJames BrugarolasAri HakimiRenal cell carcinoma is a diverse group of diseases that can be distinguished by distinct histopathologic and genomic features. In this comprehensive review, we highlight recent advancements in our understanding of the genetic and microenvironmental hallmarks of kidney cancer. We begin with clear cell renal cell carcinoma (ccRCC), the most common subtype of this disease. We review the chromosomal and genetic alterations that drive initiation and progression of ccRCC, which has recently been shown to follow multiple highly conserved evolutionary trajectories that in turn impact disease progression and prognosis. We also review the diverse genetic events that define the many recently recognized rare subtypes within non-clear cell RCC. Finally, we discuss our evolving understanding of the ccRCC microenvironment, which has been revolutionized by recent bulk and single-cell transcriptomic analyses, suggesting potential biomarkers for guiding systemic therapy in the management of advanced ccRCC.https://siuj.org/index.php/siuj/article/download/217/170renal cell carcinomaclear cell carcinomanon-clear cell renal cell carcinomageneticstumor microenvironment |
| spellingShingle | Sari Khaleel Christopher Ricketts W. Marston Linehan Mark Ball Brandon Manley Samra Turajilic James Brugarolas Ari Hakimi Genetics and Tumor Microenvironment of Renal Cell Carcinoma Société Internationale d’Urologie Journal renal cell carcinoma clear cell carcinoma non-clear cell renal cell carcinoma genetics tumor microenvironment |
| title | Genetics and Tumor Microenvironment of Renal Cell Carcinoma |
| title_full | Genetics and Tumor Microenvironment of Renal Cell Carcinoma |
| title_fullStr | Genetics and Tumor Microenvironment of Renal Cell Carcinoma |
| title_full_unstemmed | Genetics and Tumor Microenvironment of Renal Cell Carcinoma |
| title_short | Genetics and Tumor Microenvironment of Renal Cell Carcinoma |
| title_sort | genetics and tumor microenvironment of renal cell carcinoma |
| topic | renal cell carcinoma clear cell carcinoma non-clear cell renal cell carcinoma genetics tumor microenvironment |
| url | https://siuj.org/index.php/siuj/article/download/217/170 |
| work_keys_str_mv | AT sarikhaleel geneticsandtumormicroenvironmentofrenalcellcarcinoma AT christopherricketts geneticsandtumormicroenvironmentofrenalcellcarcinoma AT wmarstonlinehan geneticsandtumormicroenvironmentofrenalcellcarcinoma AT markball geneticsandtumormicroenvironmentofrenalcellcarcinoma AT brandonmanley geneticsandtumormicroenvironmentofrenalcellcarcinoma AT samraturajilic geneticsandtumormicroenvironmentofrenalcellcarcinoma AT jamesbrugarolas geneticsandtumormicroenvironmentofrenalcellcarcinoma AT arihakimi geneticsandtumormicroenvironmentofrenalcellcarcinoma |