Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis
Defining the histologic variant of thyroid carcinoma is an important clinical implication as their progression, recurrence, aggressiveness, and prognosis differ. Warthin-like variant is one of the rarest histologic variants of papillary thyroid cancer. A 36-year-old female sought consult for assessm...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/251898 |
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| author | Karla Judith González-Colunga Abelardo Loya-Solis Luis Ángel Ceceñas-Falcón Oralia Barboza-Quintana René Rodríguez-Gutiérrez |
| author_facet | Karla Judith González-Colunga Abelardo Loya-Solis Luis Ángel Ceceñas-Falcón Oralia Barboza-Quintana René Rodríguez-Gutiérrez |
| author_sort | Karla Judith González-Colunga |
| collection | DOAJ |
| description | Defining the histologic variant of thyroid carcinoma is an important clinical implication as their progression, recurrence, aggressiveness, and prognosis differ. Warthin-like variant is one of the rarest histologic variants of papillary thyroid cancer. A 36-year-old female sought consult for assessment of a painless right neck tumor. High-resolution neck ultrasound revealed a right hypoechoic, 1.71 × 1.05 cm thyroid nodule. Ultrasound-guided fine-needle aspiration biopsy report was a Bethesda grade III. Thyroid function tests showed Hashimoto’s thyroiditis. The patient underwent right hemithyroidectomy. Microscopically, the tumor was composed of papillae lined by cells with eosinophilic cytoplasm, nuclear chromatin clearing, grooves, and pseudoinclusions and a characteristic lymphoplasmacytic infiltrate of the papillae cores. Extension into the perithyroidal soft tissue and 3 ipsilateral lymph nodes was found to be positive for cancer. Warthin-like variant is an uncommon and relatively unknown variant of papillary thyroid carcinoma that has been usually associated with an excellent prognosis. Interestingly, BRAF mutations have been reported to be present in up to 75% of the patients. It is frequently associated with Hashimoto’s thyroiditis and presents unique morphological features that make it recognizable on histologic examination. The cytological diagnosis is difficult to assess due to the overlap in its findings with the classical variant and Hashimoto’s thyroiditis. |
| format | Article |
| id | doaj-art-fa6cc2e147be4d2e99e3e46f34e843ca |
| institution | DOAJ |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-fa6cc2e147be4d2e99e3e46f34e843ca2025-08-20T03:20:04ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/251898251898Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s ThyroiditisKarla Judith González-Colunga0Abelardo Loya-Solis1Luis Ángel Ceceñas-Falcón2Oralia Barboza-Quintana3René Rodríguez-Gutiérrez4Pathology Department, University Hospital “Dr. José E. González” and Medical School of the Autonomous University of Nuevo Leon, Madero and Gonzalitos s/n, 64460 Monterrey, Nuevo León, MexicoPathology Department, University Hospital “Dr. José E. González” and Medical School of the Autonomous University of Nuevo Leon, Madero and Gonzalitos s/n, 64460 Monterrey, Nuevo León, MexicoPathology Department, University Hospital “Dr. José E. González” and Medical School of the Autonomous University of Nuevo Leon, Madero and Gonzalitos s/n, 64460 Monterrey, Nuevo León, MexicoPathology Department, University Hospital “Dr. José E. González” and Medical School of the Autonomous University of Nuevo Leon, Madero and Gonzalitos s/n, 64460 Monterrey, Nuevo León, MexicoEndocrinology Division, University Hospital “Dr. José E. González” and Medical School of the Autonomous University of Nuevo Leon, Madero and Gonzalitos s/n, 64460 Monterrey, Nuevo León, MexicoDefining the histologic variant of thyroid carcinoma is an important clinical implication as their progression, recurrence, aggressiveness, and prognosis differ. Warthin-like variant is one of the rarest histologic variants of papillary thyroid cancer. A 36-year-old female sought consult for assessment of a painless right neck tumor. High-resolution neck ultrasound revealed a right hypoechoic, 1.71 × 1.05 cm thyroid nodule. Ultrasound-guided fine-needle aspiration biopsy report was a Bethesda grade III. Thyroid function tests showed Hashimoto’s thyroiditis. The patient underwent right hemithyroidectomy. Microscopically, the tumor was composed of papillae lined by cells with eosinophilic cytoplasm, nuclear chromatin clearing, grooves, and pseudoinclusions and a characteristic lymphoplasmacytic infiltrate of the papillae cores. Extension into the perithyroidal soft tissue and 3 ipsilateral lymph nodes was found to be positive for cancer. Warthin-like variant is an uncommon and relatively unknown variant of papillary thyroid carcinoma that has been usually associated with an excellent prognosis. Interestingly, BRAF mutations have been reported to be present in up to 75% of the patients. It is frequently associated with Hashimoto’s thyroiditis and presents unique morphological features that make it recognizable on histologic examination. The cytological diagnosis is difficult to assess due to the overlap in its findings with the classical variant and Hashimoto’s thyroiditis.http://dx.doi.org/10.1155/2015/251898 |
| spellingShingle | Karla Judith González-Colunga Abelardo Loya-Solis Luis Ángel Ceceñas-Falcón Oralia Barboza-Quintana René Rodríguez-Gutiérrez Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis Case Reports in Endocrinology |
| title | Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis |
| title_full | Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis |
| title_fullStr | Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis |
| title_full_unstemmed | Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis |
| title_short | Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis |
| title_sort | warthin like papillary thyroid carcinoma associated with lymphadenopathy and hashimoto s thyroiditis |
| url | http://dx.doi.org/10.1155/2015/251898 |
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