Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial
Abstract Background Colorectal cancer (CRC) patients frequently experience sleep disturbances, significantly impacting their quality of life. Cognitive behavioral therapy for insomnia (CBT-I) is considered the first-line treatment but is often complex, costly, and requires highly trained therapists....
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-12-01
|
| Series: | Journal of Cancer Research and Clinical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s00432-024-06065-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823863323784904704 |
|---|---|
| author | Anlong Li Runze Huang Han Ge Dajie Liu Shaochun Liu Yingxue Jia Jiaying Chai Xinyi Zheng Lijun Liu Chen Gan Jian Xu Ling Cheng Mingjun Zhang Huaidong Cheng |
| author_facet | Anlong Li Runze Huang Han Ge Dajie Liu Shaochun Liu Yingxue Jia Jiaying Chai Xinyi Zheng Lijun Liu Chen Gan Jian Xu Ling Cheng Mingjun Zhang Huaidong Cheng |
| author_sort | Anlong Li |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) patients frequently experience sleep disturbances, significantly impacting their quality of life. Cognitive behavioral therapy for insomnia (CBT-I) is considered the first-line treatment but is often complex, costly, and requires highly trained therapists. Behavioral activation (BA), derived from cognitive behavioral therapy (CBT), offers a flexible, simple, and cost-effective alternative. BA highlights the importance of activation, a strategy that encourages active participation in positive, meaningful activities to boost positive experiences and reduce negative emotions, which may have potential benefits for individuals with sleep disorders. This study explores the effects of BA on sleep disturbances, quality of life, and psychological distress in CRC patients and investigates potential underlying mechanisms. Methods The study included 101 CRC patients with sleep disturbances, who were randomly assigned to either the BA group (n = 53) or the usual care (UC) group (n = 48). Assessments of quality of life, sleep disturbances, psychological distress, activation, avoidance, and physical activity levels were conducted at baseline (T0), four weeks later (T1), and post-intervention (T2). Generalized estimating equation (GEE) analysis was used to evaluate the intervention’s impact and potential mediating effects. Results The BA group experienced significant improvements in sleep disturbances (Wald's χ2 = 7.979, P = 0.019), enhanced quality of life (Wald's χ2 = 6.435.P = 0.04), and reduced psychological distress (Wald's χ2 = 56.728, P < 0.001) compared to the UC group. Physical activity (P < 0.001) partially mediated the intervention effects of BA on sleep disturbances, while activation (P = 0.073) demonstrated marginal mediating effects. Conclusion BA is an effective psychological intervention that significantly improves sleep disturbances, enhances quality of life, and alleviates psychological distress in CRC patients. Mediator analysis indicates that physical activity partially mediates the effects of BA on sleep disturbances, with activation showing marginal significance. Future research should further investigate the underlying mechanisms and long-term effects of BA on sleep disturbances. |
| format | Article |
| id | doaj-art-fa69bea4d8ac4c16b3d66d694abaecdb |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-fa69bea4d8ac4c16b3d66d694abaecdb2025-02-09T12:10:07ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352024-12-01151111210.1007/s00432-024-06065-xExploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trialAnlong Li0Runze Huang1Han Ge2Dajie Liu3Shaochun Liu4Yingxue Jia5Jiaying Chai6Xinyi Zheng7Lijun Liu8Chen Gan9Jian Xu10Ling Cheng11Mingjun Zhang12Huaidong Cheng13Department of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityThe Third School of Clinical Medicine, Southern Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityOncology, Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian)Department of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, the Second Affiliated Hospital of Anhui Medical UniversityAbstract Background Colorectal cancer (CRC) patients frequently experience sleep disturbances, significantly impacting their quality of life. Cognitive behavioral therapy for insomnia (CBT-I) is considered the first-line treatment but is often complex, costly, and requires highly trained therapists. Behavioral activation (BA), derived from cognitive behavioral therapy (CBT), offers a flexible, simple, and cost-effective alternative. BA highlights the importance of activation, a strategy that encourages active participation in positive, meaningful activities to boost positive experiences and reduce negative emotions, which may have potential benefits for individuals with sleep disorders. This study explores the effects of BA on sleep disturbances, quality of life, and psychological distress in CRC patients and investigates potential underlying mechanisms. Methods The study included 101 CRC patients with sleep disturbances, who were randomly assigned to either the BA group (n = 53) or the usual care (UC) group (n = 48). Assessments of quality of life, sleep disturbances, psychological distress, activation, avoidance, and physical activity levels were conducted at baseline (T0), four weeks later (T1), and post-intervention (T2). Generalized estimating equation (GEE) analysis was used to evaluate the intervention’s impact and potential mediating effects. Results The BA group experienced significant improvements in sleep disturbances (Wald's χ2 = 7.979, P = 0.019), enhanced quality of life (Wald's χ2 = 6.435.P = 0.04), and reduced psychological distress (Wald's χ2 = 56.728, P < 0.001) compared to the UC group. Physical activity (P < 0.001) partially mediated the intervention effects of BA on sleep disturbances, while activation (P = 0.073) demonstrated marginal mediating effects. Conclusion BA is an effective psychological intervention that significantly improves sleep disturbances, enhances quality of life, and alleviates psychological distress in CRC patients. Mediator analysis indicates that physical activity partially mediates the effects of BA on sleep disturbances, with activation showing marginal significance. Future research should further investigate the underlying mechanisms and long-term effects of BA on sleep disturbances.https://doi.org/10.1007/s00432-024-06065-xColorectal cancerSleepBehavioral activationQuality of lifePhysical activity |
| spellingShingle | Anlong Li Runze Huang Han Ge Dajie Liu Shaochun Liu Yingxue Jia Jiaying Chai Xinyi Zheng Lijun Liu Chen Gan Jian Xu Ling Cheng Mingjun Zhang Huaidong Cheng Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial Journal of Cancer Research and Clinical Oncology Colorectal cancer Sleep Behavioral activation Quality of life Physical activity |
| title | Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial |
| title_full | Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial |
| title_fullStr | Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial |
| title_full_unstemmed | Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial |
| title_short | Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial |
| title_sort | exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer a randomized controlled trial |
| topic | Colorectal cancer Sleep Behavioral activation Quality of life Physical activity |
| url | https://doi.org/10.1007/s00432-024-06065-x |
| work_keys_str_mv | AT anlongli exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT runzehuang exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT hange exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT dajieliu exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT shaochunliu exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT yingxuejia exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT jiayingchai exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT xinyizheng exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT lijunliu exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT chengan exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT jianxu exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT lingcheng exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT mingjunzhang exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial AT huaidongcheng exploringtheimpactandmechanismsofbehavioralactivationonsleepdisordersincolorectalcancerarandomizedcontrolledtrial |