Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan

The purpose of the present study was to examine the effect of single embryo transfer (SET) in assisted reproductive technology (ART) on the reduction of the multiple pregnancy rate. We also estimated the monozygotic (MZ) twinning rates according to the SET diffusion indirectly. A reverse sigmoid cur...

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Main Author: Syuichi Ooki
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Pregnancy
Online Access:http://dx.doi.org/10.1155/2012/620753
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author Syuichi Ooki
author_facet Syuichi Ooki
author_sort Syuichi Ooki
collection DOAJ
description The purpose of the present study was to examine the effect of single embryo transfer (SET) in assisted reproductive technology (ART) on the reduction of the multiple pregnancy rate. We also estimated the monozygotic (MZ) twinning rates according to the SET diffusion indirectly. A reverse sigmoid curve was assumed and examined using nationwide data of SET from 2007 to 2009 in Japan. The multiple pregnancy rate decreased almost linearly where the SET pregnancy rate was between about 40% and 80% of regression approximation. The linear approximation overestimated multiple pregnancy rates in an early period and underestimated multiple pregnancy rates in the final period. The multiple pregnancy rate seemed to be influenced by the improvement of the total pregnancy rate of ART in the early period and by the MZ twinning after SET in the final period. The estimated MZ twinning rate after SET was around 2%.
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institution Kabale University
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publishDate 2012-01-01
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series Journal of Pregnancy
spelling doaj-art-fa6892b9d1a447138f73bb881f29d89e2025-02-03T05:44:26ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/620753620753Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in JapanSyuichi Ooki0Department of Health Science, Ishikawa Prefectural Nursing University, 1-1, Gakuendai, Kahoku 929-1210, JapanThe purpose of the present study was to examine the effect of single embryo transfer (SET) in assisted reproductive technology (ART) on the reduction of the multiple pregnancy rate. We also estimated the monozygotic (MZ) twinning rates according to the SET diffusion indirectly. A reverse sigmoid curve was assumed and examined using nationwide data of SET from 2007 to 2009 in Japan. The multiple pregnancy rate decreased almost linearly where the SET pregnancy rate was between about 40% and 80% of regression approximation. The linear approximation overestimated multiple pregnancy rates in an early period and underestimated multiple pregnancy rates in the final period. The multiple pregnancy rate seemed to be influenced by the improvement of the total pregnancy rate of ART in the early period and by the MZ twinning after SET in the final period. The estimated MZ twinning rate after SET was around 2%.http://dx.doi.org/10.1155/2012/620753
spellingShingle Syuichi Ooki
Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan
Journal of Pregnancy
title Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan
title_full Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan
title_fullStr Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan
title_full_unstemmed Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan
title_short Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan
title_sort theoretical model of the relationship between single embryo transfer rate and multiple pregnancy rate in japan
url http://dx.doi.org/10.1155/2012/620753
work_keys_str_mv AT syuichiooki theoreticalmodeloftherelationshipbetweensingleembryotransferrateandmultiplepregnancyrateinjapan