mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets
Diabetic nephropathy is a prevalent complication of diabetes and stands as the primary contributor to end-stage renal disease. The global prevalence of diabetic nephropathy is on the rise, however, due to its intricate pathogenesis, there is currently an absence of efficacious treatments to enhance...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224000576 |
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| author | Jingxuan Shi Xinze Liu Yuanyuan Jiao Jingwei Tian Jiaqi An Guming Zou Li Zhuo |
| author_facet | Jingxuan Shi Xinze Liu Yuanyuan Jiao Jingwei Tian Jiaqi An Guming Zou Li Zhuo |
| author_sort | Jingxuan Shi |
| collection | DOAJ |
| description | Diabetic nephropathy is a prevalent complication of diabetes and stands as the primary contributor to end-stage renal disease. The global prevalence of diabetic nephropathy is on the rise, however, due to its intricate pathogenesis, there is currently an absence of efficacious treatments to enhance renal prognosis in affected patients. The mammalian target of rapamycin (mTOR), a serine/threonine protease, assumes a pivotal role in cellular division, survival, apoptosis delay, and angiogenesis. It is implicated in diverse signaling pathways and has been observed to partake in the progression of diabetic nephropathy by inhibiting autophagy, promoting inflammation, and increasing oxidative stress. In this academic review, we have consolidated the understanding of the pathological mechanisms associated with four distinct resident renal cell types (podocytes, glomerular mesangial cells, renal tubular epithelial cells, and glomerular endothelial cells), as well as macrophages and T lymphocytes, within a diabetic environment. Additionally, we highlight the research progress in the treatment of diabetic nephropathy with drugs and various molecules interfering with the mTOR signaling pathway, providing a theoretical reference for the treatment and prevention of diabetic nephropathy. |
| format | Article |
| id | doaj-art-fa66d27490a9486cbd3f7e42b1102b8c |
| institution | OA Journals |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-fa66d27490a9486cbd3f7e42b1102b8c2025-08-20T02:35:29ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-03-0112210126010.1016/j.gendis.2024.101260mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targetsJingxuan Shi0Xinze Liu1Yuanyuan Jiao2Jingwei Tian3Jiaqi An4Guming Zou5Li Zhuo6Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China; China-Japan Friendship Institute of Clinical Medical Sciences, Beijing 100029, ChinaBeijing University of Chinese Medicine China-Japan Friendship Clinical Medical College, Beijing 100029, ChinaDepartment of Nephrology, Fuwai Hospital, Chinese Academy of Medical Science, Beijing 100037, ChinaDepartment of Nephrology, Beijing Sixth Hospital, Beijing 100007, China; Capital Medical University China-Japan Friendship School of Clinical Medicine, Beijing 100029, ChinaDepartment of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China; China-Japan Friendship Clinic Medical College, Peking University, Beijing 100191, ChinaDepartment of Nephrology, China-Japan Friendship Hospital, Beijing 100029, ChinaDepartment of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China; Corresponding author. China-Japan Friendship Hospital, No.2, East Yinghuayuan Street, Beijing 100029, China.Diabetic nephropathy is a prevalent complication of diabetes and stands as the primary contributor to end-stage renal disease. The global prevalence of diabetic nephropathy is on the rise, however, due to its intricate pathogenesis, there is currently an absence of efficacious treatments to enhance renal prognosis in affected patients. The mammalian target of rapamycin (mTOR), a serine/threonine protease, assumes a pivotal role in cellular division, survival, apoptosis delay, and angiogenesis. It is implicated in diverse signaling pathways and has been observed to partake in the progression of diabetic nephropathy by inhibiting autophagy, promoting inflammation, and increasing oxidative stress. In this academic review, we have consolidated the understanding of the pathological mechanisms associated with four distinct resident renal cell types (podocytes, glomerular mesangial cells, renal tubular epithelial cells, and glomerular endothelial cells), as well as macrophages and T lymphocytes, within a diabetic environment. Additionally, we highlight the research progress in the treatment of diabetic nephropathy with drugs and various molecules interfering with the mTOR signaling pathway, providing a theoretical reference for the treatment and prevention of diabetic nephropathy.http://www.sciencedirect.com/science/article/pii/S2352304224000576BibliometricsDiabetic nephropathyGlomerular endothelial cellImmune cellMesangial cellmTOR |
| spellingShingle | Jingxuan Shi Xinze Liu Yuanyuan Jiao Jingwei Tian Jiaqi An Guming Zou Li Zhuo mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets Genes and Diseases Bibliometrics Diabetic nephropathy Glomerular endothelial cell Immune cell Mesangial cell mTOR |
| title | mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets |
| title_full | mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets |
| title_fullStr | mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets |
| title_full_unstemmed | mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets |
| title_short | mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets |
| title_sort | mtor pathway a key player in diabetic nephropathy progression and therapeutic targets |
| topic | Bibliometrics Diabetic nephropathy Glomerular endothelial cell Immune cell Mesangial cell mTOR |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224000576 |
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