Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia.
Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer chemotherapy. However, the neural mechanisms underlying CNP remain unclear. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neuropathic pain. In this study, we used a vin...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089583&type=printable |
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| author | Yang Yang Yong-Gang Zhang Guo-An Lin He-Qiu Xie Hai-Tao Pan Ben-Qing Huang Ji-Dong Liu Hui Liu Nan Zhang Li Li Jian-Hua Chen |
| author_facet | Yang Yang Yong-Gang Zhang Guo-An Lin He-Qiu Xie Hai-Tao Pan Ben-Qing Huang Ji-Dong Liu Hui Liu Nan Zhang Li Li Jian-Hua Chen |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer chemotherapy. However, the neural mechanisms underlying CNP remain unclear. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neuropathic pain. In this study, we used a vincristine-evoked rat CNP model displaying mechanical allodynia and central sensitization, and observed a significant decrease in the expression of spinal EM2 in CNP. Also, while intrathecal administration of exogenous EM2 attenuated allodynia and central sensitization, the mu-opioid receptor antagonist β-funaltrexamine facilitated these events. We found that the reduction in spinal EM2 was mediated by increased activity of dipeptidylpeptidase IV, possibly as a consequence of chemotherapy-induced oxidative stress. Taken together, our findings suggest that a decrease in spinal EM2 expression causes the loss of endogenous analgesia and leads to enhanced pain sensation in CNP. |
| format | Article |
| id | doaj-art-fa628c861ba64c1f863c01733f5cbfd0 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fa628c861ba64c1f863c01733f5cbfd02025-08-20T03:01:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8958310.1371/journal.pone.0089583Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia.Yang YangYong-Gang ZhangGuo-An LinHe-Qiu XieHai-Tao PanBen-Qing HuangJi-Dong LiuHui LiuNan ZhangLi LiJian-Hua ChenChemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer chemotherapy. However, the neural mechanisms underlying CNP remain unclear. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neuropathic pain. In this study, we used a vincristine-evoked rat CNP model displaying mechanical allodynia and central sensitization, and observed a significant decrease in the expression of spinal EM2 in CNP. Also, while intrathecal administration of exogenous EM2 attenuated allodynia and central sensitization, the mu-opioid receptor antagonist β-funaltrexamine facilitated these events. We found that the reduction in spinal EM2 was mediated by increased activity of dipeptidylpeptidase IV, possibly as a consequence of chemotherapy-induced oxidative stress. Taken together, our findings suggest that a decrease in spinal EM2 expression causes the loss of endogenous analgesia and leads to enhanced pain sensation in CNP.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089583&type=printable |
| spellingShingle | Yang Yang Yong-Gang Zhang Guo-An Lin He-Qiu Xie Hai-Tao Pan Ben-Qing Huang Ji-Dong Liu Hui Liu Nan Zhang Li Li Jian-Hua Chen Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia. PLoS ONE |
| title | Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia. |
| title_full | Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia. |
| title_fullStr | Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia. |
| title_full_unstemmed | Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia. |
| title_short | Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia. |
| title_sort | spinal changes of a newly isolated neuropeptide endomorphin 2 concomitant with vincristine induced allodynia |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089583&type=printable |
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