Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention
Abstract An international expert panel convened to evaluate nutrition-based approaches to brain health and dementia prevention. This consensus statement integrates perspectives from lived experiences, mechanistic evidence, epidemiology, and clinical interventions. Nutrition plays a crucial role in b...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-025-00981-6 |
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| author | Alexandra M. Johnstone Emiliano Albanese Daniel R. Crabtree Boushra Dalile Stefanie Grabrucker Jenna M. Gregory Giuseppe Grosso Adrian Holliday Catherine Hughes Catherine Itsiopoulos John Mamo Claire McEvoy Phyo Kyaw Myint Leticia Radin Pereira David Vauzour Mario Siervo |
| author_facet | Alexandra M. Johnstone Emiliano Albanese Daniel R. Crabtree Boushra Dalile Stefanie Grabrucker Jenna M. Gregory Giuseppe Grosso Adrian Holliday Catherine Hughes Catherine Itsiopoulos John Mamo Claire McEvoy Phyo Kyaw Myint Leticia Radin Pereira David Vauzour Mario Siervo |
| author_sort | Alexandra M. Johnstone |
| collection | DOAJ |
| description | Abstract An international expert panel convened to evaluate nutrition-based approaches to brain health and dementia prevention. This consensus statement integrates perspectives from lived experiences, mechanistic evidence, epidemiology, and clinical interventions. Nutrition plays a crucial role in brain health throughout life and in cognitive decline pathogenesis, particularly through the food-gut-brain axis. Intervention effectiveness varies across the health promotion, prevention, treatment, and maintenance spectrum due to methodological differences and individual responses to nutritional interventions. The Mediterranean and MIND dietary patterns show promise for maintaining cognitive function across studies. Multi-domain interventions like FINGER effectively combine dietary modifications with lifestyle changes to delay dementia onset in at-risk older adults. These findings align with mechanistic evidence on the food-gut-brain axis in maintaining optimal brain health by preventing neurodegeneration. Key mechanisms include gut microbiota composition and function, blood-brain barrier integrity, endothelial and mitochondrial dysfunction, insulin resistance, oxidative stress, and inflammatory processes. Research priorities include standardizing cognitive assessment methodologies, developing early intervention strategies, and implementing integrated precision nutrition and lifestyle approaches. Incorporating patients’ and caregivers’ lived experiences in research co-production was identified as essential to support those with lived experience. The panel concluded that future directions should combine population and individual-level preventive approaches while addressing challenges in sustaining healthy behavioral changes and understanding the complex interplay between diet, lifestyle, and genetic factors in brain health and dementia prevention. Experts emphasized the need for both standardized methodologies and personalized interventions to account for individual variability in nutritional responses and facilitate effective prevention strategies across diverse populations. |
| format | Article |
| id | doaj-art-fa613dd9620b46ca9a202a83e40b6206 |
| institution | Kabale University |
| issn | 1743-7075 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj-art-fa613dd9620b46ca9a202a83e40b62062025-08-20T03:42:37ZengBMCNutrition & Metabolism1743-70752025-07-0122111810.1186/s12986-025-00981-6Consensus statement on exploring the Nexus between nutrition, brain health and dementia preventionAlexandra M. Johnstone0Emiliano Albanese1Daniel R. Crabtree2Boushra Dalile3Stefanie Grabrucker4Jenna M. Gregory5Giuseppe Grosso6Adrian Holliday7Catherine Hughes8Catherine Itsiopoulos9John Mamo10Claire McEvoy11Phyo Kyaw Myint12Leticia Radin Pereira13David Vauzour14Mario Siervo15University of AberdeenUniversità della Svizzera ItalianaUniversity of AberdeenLaboratory of Biological Psychology, KU LeuvenDepartment of Anatomy and Neuroscience, University College CorkUniversity of AberdeenDepartment of Biomedical and Biotechnological Sciences, University of CataniaSchool of Biomedical, Nutritional, and Sport Science, Faculty of Medical Sciences, Newcastle UniversityUlster UniversityRMIT UniversitySchool of Population Health, Curtin UniversityCentre for Public Health, Institute for Global Food Security, Queen’s University BelfastUniversity of AberdeenDepartment of Community Health Sciences, Cumming School of Medicine, University of CalgaryUniversity of East AngliaSchool of Population Health, Curtin UniversityAbstract An international expert panel convened to evaluate nutrition-based approaches to brain health and dementia prevention. This consensus statement integrates perspectives from lived experiences, mechanistic evidence, epidemiology, and clinical interventions. Nutrition plays a crucial role in brain health throughout life and in cognitive decline pathogenesis, particularly through the food-gut-brain axis. Intervention effectiveness varies across the health promotion, prevention, treatment, and maintenance spectrum due to methodological differences and individual responses to nutritional interventions. The Mediterranean and MIND dietary patterns show promise for maintaining cognitive function across studies. Multi-domain interventions like FINGER effectively combine dietary modifications with lifestyle changes to delay dementia onset in at-risk older adults. These findings align with mechanistic evidence on the food-gut-brain axis in maintaining optimal brain health by preventing neurodegeneration. Key mechanisms include gut microbiota composition and function, blood-brain barrier integrity, endothelial and mitochondrial dysfunction, insulin resistance, oxidative stress, and inflammatory processes. Research priorities include standardizing cognitive assessment methodologies, developing early intervention strategies, and implementing integrated precision nutrition and lifestyle approaches. Incorporating patients’ and caregivers’ lived experiences in research co-production was identified as essential to support those with lived experience. The panel concluded that future directions should combine population and individual-level preventive approaches while addressing challenges in sustaining healthy behavioral changes and understanding the complex interplay between diet, lifestyle, and genetic factors in brain health and dementia prevention. Experts emphasized the need for both standardized methodologies and personalized interventions to account for individual variability in nutritional responses and facilitate effective prevention strategies across diverse populations.https://doi.org/10.1186/s12986-025-00981-6AgeingDietNutritionCo-productionMechanismsBrain health |
| spellingShingle | Alexandra M. Johnstone Emiliano Albanese Daniel R. Crabtree Boushra Dalile Stefanie Grabrucker Jenna M. Gregory Giuseppe Grosso Adrian Holliday Catherine Hughes Catherine Itsiopoulos John Mamo Claire McEvoy Phyo Kyaw Myint Leticia Radin Pereira David Vauzour Mario Siervo Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention Nutrition & Metabolism Ageing Diet Nutrition Co-production Mechanisms Brain health |
| title | Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention |
| title_full | Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention |
| title_fullStr | Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention |
| title_full_unstemmed | Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention |
| title_short | Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention |
| title_sort | consensus statement on exploring the nexus between nutrition brain health and dementia prevention |
| topic | Ageing Diet Nutrition Co-production Mechanisms Brain health |
| url | https://doi.org/10.1186/s12986-025-00981-6 |
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