Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients
Background/Aims Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are limited. Therefore, we compared the clinical ch...
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The Korean Association of Internal Medicine
2025-05-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://kjim.org/upload/kjim-2024-250.pdf |
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| author | Yuri Kim Do Hoon Kim Myeongsook Seo Hee Kyong Na Kee Wook Jung Ji Yong Ahn Jeong Hoon Lee Kee Don Choi Ho June Song Gin Hyug Lee Hwoon-Yong Jung |
| author_facet | Yuri Kim Do Hoon Kim Myeongsook Seo Hee Kyong Na Kee Wook Jung Ji Yong Ahn Jeong Hoon Lee Kee Don Choi Ho June Song Gin Hyug Lee Hwoon-Yong Jung |
| author_sort | Yuri Kim |
| collection | DOAJ |
| description | Background/Aims Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are limited. Therefore, we compared the clinical characteristics, endoscopic findings, and outcomes of UGI CMV disease in non-transplant patients with those in transplant recipients. Methods We reviewed the medical records of patients diagnosed with UGI CMV disease between May 1999 and January 2022. UGI CMV disease was defined as symptoms or signs of gastrointestinal disease with typical findings of CMV inclusion body and positive immunochemistry stain or CMV polymerase chain reaction from the endoscopic biopsy specimen. Results Among the 219 eligible patients, 132 (60.3%) were transplant patients. Age, male sex, and Charlson Comorbidity Index were significantly higher in the non-transplant group than in the transplant group. The most common symptoms were pain and odynophagia (43.8%). Transplant recipients more frequently experienced UGI CMV disease in the stomach than non-transplant patients, typically presenting as erosions or mucosal hyperemia. However, non-transplant patients more commonly experienced UGI CMV disease in the esophagus than transplant recipients, typically presenting as ulcers. The transplant group had a significantly higher clinical response than the non-transplant group. Conclusions UGI CMV disease in transplant patients can be present in the stomach in various forms, including ulcers or erosions. In transplant patients suspected of UGI CMV disease, conducting an esophagogastroduodenoscopy with tissue biopsy in any area where even the slightest mucosal abnormality is observed is essential to facilitate a prompt diagnosis. |
| format | Article |
| id | doaj-art-fa60f43a35dc4353b3b6bb02022b7d57 |
| institution | OA Journals |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-fa60f43a35dc4353b3b6bb02022b7d572025-08-20T02:32:18ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-05-0140339440310.3904/kjim.2024.250171011Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patientsYuri Kim0Do Hoon Kim1Myeongsook Seo2Hee Kyong Na3Kee Wook Jung4Ji Yong Ahn5Jeong Hoon Lee6Kee Don Choi7Ho June Song8Gin Hyug Lee9Hwoon-Yong Jung10 Division of Gastroenterology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground/Aims Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are limited. Therefore, we compared the clinical characteristics, endoscopic findings, and outcomes of UGI CMV disease in non-transplant patients with those in transplant recipients. Methods We reviewed the medical records of patients diagnosed with UGI CMV disease between May 1999 and January 2022. UGI CMV disease was defined as symptoms or signs of gastrointestinal disease with typical findings of CMV inclusion body and positive immunochemistry stain or CMV polymerase chain reaction from the endoscopic biopsy specimen. Results Among the 219 eligible patients, 132 (60.3%) were transplant patients. Age, male sex, and Charlson Comorbidity Index were significantly higher in the non-transplant group than in the transplant group. The most common symptoms were pain and odynophagia (43.8%). Transplant recipients more frequently experienced UGI CMV disease in the stomach than non-transplant patients, typically presenting as erosions or mucosal hyperemia. However, non-transplant patients more commonly experienced UGI CMV disease in the esophagus than transplant recipients, typically presenting as ulcers. The transplant group had a significantly higher clinical response than the non-transplant group. Conclusions UGI CMV disease in transplant patients can be present in the stomach in various forms, including ulcers or erosions. In transplant patients suspected of UGI CMV disease, conducting an esophagogastroduodenoscopy with tissue biopsy in any area where even the slightest mucosal abnormality is observed is essential to facilitate a prompt diagnosis.http://kjim.org/upload/kjim-2024-250.pdfcytomegalovirusendoscopyimmunocompromised hosttransplantationchemotherapy |
| spellingShingle | Yuri Kim Do Hoon Kim Myeongsook Seo Hee Kyong Na Kee Wook Jung Ji Yong Ahn Jeong Hoon Lee Kee Don Choi Ho June Song Gin Hyug Lee Hwoon-Yong Jung Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients The Korean Journal of Internal Medicine cytomegalovirus endoscopy immunocompromised host transplantation chemotherapy |
| title | Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients |
| title_full | Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients |
| title_fullStr | Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients |
| title_full_unstemmed | Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients |
| title_short | Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients |
| title_sort | endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non transplant patients |
| topic | cytomegalovirus endoscopy immunocompromised host transplantation chemotherapy |
| url | http://kjim.org/upload/kjim-2024-250.pdf |
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