The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial.
<h4>Background</h4>Despite the impact and prevalence of Attention Deficit Hyperactivity Disorder (ADHD), current treatment options remain limited and there is a drive for alternative approaches, including those building on evidence of a role for tryptophan (TRP) and serotonin (5-HT). Thi...
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Public Library of Science (PLoS)
2023-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294911&type=printable |
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| author | Larisa M Dinu Samriddhi N Singh Neo S Baker Alexandra L Georgescu Paul G Overton Eleanor J Dommett |
| author_facet | Larisa M Dinu Samriddhi N Singh Neo S Baker Alexandra L Georgescu Paul G Overton Eleanor J Dommett |
| author_sort | Larisa M Dinu |
| collection | DOAJ |
| description | <h4>Background</h4>Despite the impact and prevalence of Attention Deficit Hyperactivity Disorder (ADHD), current treatment options remain limited and there is a drive for alternative approaches, including those building on evidence of a role for tryptophan (TRP) and serotonin (5-HT). This study aimed to evaluate the effect of acute TRP loading on attention and impulsivity in adults with ADHD.<h4>Trial design and methods</h4>We conducted a remote double blind randomised controlled trial (RCT) using TRP loading to examine the effects of a balanced amino acid load in comparison to low and high TRP loading in individuals with ADHD (medicated, N = 48, and unmedicated, N = 46) and controls (N = 50). Participants were randomised into one of three TRP treatment groups using stratified randomisation considering participant group and gender using a 1:1:1 ratio. Baseline testing of attention and impulsivity using the Test of Variables of Attention Task, Delay Discounting Task, and Iowa Gambling Task was followed by consumption of a protein drink (BAL, LOW, or HIGH TRP) before repeated testing.<h4>Results and conclusions</h4>No effects of TRP were observed for any of the measures. In the present study, TRP loading did not impact on any measure of attention or impulsivity in those with ADHD or Controls. The findings need to be confirmed in another trial with a larger number of patients that also considers additional measures of dietary protein, plasma TRP and aggression. (Registration ID ISRCTN15119603). |
| format | Article |
| id | doaj-art-fa60563000d447aea433f75d269d2a6f |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fa60563000d447aea433f75d269d2a6f2025-08-20T02:36:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011811e029491110.1371/journal.pone.0294911The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial.Larisa M DinuSamriddhi N SinghNeo S BakerAlexandra L GeorgescuPaul G OvertonEleanor J Dommett<h4>Background</h4>Despite the impact and prevalence of Attention Deficit Hyperactivity Disorder (ADHD), current treatment options remain limited and there is a drive for alternative approaches, including those building on evidence of a role for tryptophan (TRP) and serotonin (5-HT). This study aimed to evaluate the effect of acute TRP loading on attention and impulsivity in adults with ADHD.<h4>Trial design and methods</h4>We conducted a remote double blind randomised controlled trial (RCT) using TRP loading to examine the effects of a balanced amino acid load in comparison to low and high TRP loading in individuals with ADHD (medicated, N = 48, and unmedicated, N = 46) and controls (N = 50). Participants were randomised into one of three TRP treatment groups using stratified randomisation considering participant group and gender using a 1:1:1 ratio. Baseline testing of attention and impulsivity using the Test of Variables of Attention Task, Delay Discounting Task, and Iowa Gambling Task was followed by consumption of a protein drink (BAL, LOW, or HIGH TRP) before repeated testing.<h4>Results and conclusions</h4>No effects of TRP were observed for any of the measures. In the present study, TRP loading did not impact on any measure of attention or impulsivity in those with ADHD or Controls. The findings need to be confirmed in another trial with a larger number of patients that also considers additional measures of dietary protein, plasma TRP and aggression. (Registration ID ISRCTN15119603).https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294911&type=printable |
| spellingShingle | Larisa M Dinu Samriddhi N Singh Neo S Baker Alexandra L Georgescu Paul G Overton Eleanor J Dommett The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial. PLoS ONE |
| title | The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial. |
| title_full | The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial. |
| title_fullStr | The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial. |
| title_full_unstemmed | The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial. |
| title_short | The effects of tryptophan loading on Attention Deficit Hyperactivity Disorder in adults: A remote double blind randomised controlled trial. |
| title_sort | effects of tryptophan loading on attention deficit hyperactivity disorder in adults a remote double blind randomised controlled trial |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294911&type=printable |
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