Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiography
AIM: To evaluate the mid-term effects of topical latanoprost 0.005% on vessel density (VD) of the bulbar conjunctiva using anterior segment optical coherence tomography angiography (OCTA). METHODS: Thirty-four eyes of 21 patients and 18 eyes of 9 healthy subjects were recruited as the treatment and...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-08-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/8/20250806.pdf |
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| author | Zakieh Vahedian Ali Azimi Seyed Mehdi Tabatabaei Ghasem Fakhraie |
| author_facet | Zakieh Vahedian Ali Azimi Seyed Mehdi Tabatabaei Ghasem Fakhraie |
| author_sort | Zakieh Vahedian |
| collection | DOAJ |
| description | AIM: To evaluate the mid-term effects of topical latanoprost 0.005% on vessel density (VD) of the bulbar conjunctiva using anterior segment optical coherence tomography angiography (OCTA). METHODS: Thirty-four eyes of 21 patients and 18 eyes of 9 healthy subjects were recruited as the treatment and control groups, respectively. The treatment group was instructed to apply generic latanoprost 0.005% once daily at night, while the control group received no medication. Anterior segment OCTA was performed on all eyes at baseline, 3wk, and 12wk after initiation of latanoprost. The superficial bulbar conjunctival VD was measured in the superior, inferior, temporal, and nasal quadrants. A linear mixed model was used to compare the change in the VD between groups. RESULTS: The change in the VD was not different between groups in temporal, and nasal quadrants at 3-week and 12-week time points. The VD in the superior bulbar conjunctiva was significantly increased after 12wk (P=0.029) while the change from baseline after 3wk was not different between groups (P=0.218). After adjustment for age and gender superior hemi (P=0.006) and center (P=0.016) of the inferior quadrant of bulbar conjunctiva showed increased VD after 12wk. CONCLUSION: The trend of changes in the superior and inferior conjunctival VD is increased following topical latanoprost administration and these changes can be quantified using anterior segment OCTA. |
| format | Article |
| id | doaj-art-fa5e3d548dea4bc6ab88f73853b73f94 |
| institution | OA Journals |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-fa5e3d548dea4bc6ab88f73853b73f942025-08-20T02:38:53ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-08-011881464146910.18240/ijo.2025.08.0620250806Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiographyZakieh Vahedian0Ali Azimi1Seyed Mehdi Tabatabaei2Ghasem Fakhraie3Seyed Mehdi Tabatabaei. Farabi Eye Hospital, Qazvin Square, Tehran 1336616351, Iran. meh.tabatabaei@gmail.comGlaucoma Service, Farabi Eye Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran 1336616351, Iran; Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7134997446, IranGlaucoma Service, Farabi Eye Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran 1336616351, IranGlaucoma Service, Farabi Eye Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran 1336616351, IranAIM: To evaluate the mid-term effects of topical latanoprost 0.005% on vessel density (VD) of the bulbar conjunctiva using anterior segment optical coherence tomography angiography (OCTA). METHODS: Thirty-four eyes of 21 patients and 18 eyes of 9 healthy subjects were recruited as the treatment and control groups, respectively. The treatment group was instructed to apply generic latanoprost 0.005% once daily at night, while the control group received no medication. Anterior segment OCTA was performed on all eyes at baseline, 3wk, and 12wk after initiation of latanoprost. The superficial bulbar conjunctival VD was measured in the superior, inferior, temporal, and nasal quadrants. A linear mixed model was used to compare the change in the VD between groups. RESULTS: The change in the VD was not different between groups in temporal, and nasal quadrants at 3-week and 12-week time points. The VD in the superior bulbar conjunctiva was significantly increased after 12wk (P=0.029) while the change from baseline after 3wk was not different between groups (P=0.218). After adjustment for age and gender superior hemi (P=0.006) and center (P=0.016) of the inferior quadrant of bulbar conjunctiva showed increased VD after 12wk. CONCLUSION: The trend of changes in the superior and inferior conjunctival VD is increased following topical latanoprost administration and these changes can be quantified using anterior segment OCTA.http://ies.ijo.cn/en_publish/2025/8/20250806.pdflatanoprostconjunctival hyperemiaconjunctival vessel densityanterior segment optical coherence tomography angiography |
| spellingShingle | Zakieh Vahedian Ali Azimi Seyed Mehdi Tabatabaei Ghasem Fakhraie Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiography International Journal of Ophthalmology latanoprost conjunctival hyperemia conjunctival vessel density anterior segment optical coherence tomography angiography |
| title | Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiography |
| title_full | Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiography |
| title_fullStr | Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiography |
| title_full_unstemmed | Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiography |
| title_short | Quantifying latanoprost-induced conjunctival hyperemia by anterior segment optical coherence tomography angiography |
| title_sort | quantifying latanoprost induced conjunctival hyperemia by anterior segment optical coherence tomography angiography |
| topic | latanoprost conjunctival hyperemia conjunctival vessel density anterior segment optical coherence tomography angiography |
| url | http://ies.ijo.cn/en_publish/2025/8/20250806.pdf |
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