Doxorubicin-mediated testicular toxicity is associated with dysregulated mTOR/Beclin-1 pathways, oxidative stress, inflammation and apoptosis in Wistar rats: preventive role of lutein

Doxorubicin-mediated testicular toxicity is associated with dysregulated mTOR/Beclin-1 pathways, oxidative stress, inflammation and apoptosis in Wistar rats: preventive role of lutein

Abstract Background Lutein offers undoubted hope for preventing doxorubicin uncharacteristic reproductive function which remains a worldwide health concern in cancer chemotherapy. However, the mechanisms underlying the effect of lutein on maintaining the male reproductive milieu have not yet been fu...

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Main Authors: Jennifer Efe Jaiyeoba-Ojigho, Jerome Ndudi Asiwe, Joseph Chimezie, Blessing Oluwakemi Abe, Oghenemarho Monalisa Ataikiru, Taniyohwo Mamerhi Enaohwo, Alexander Obidike Naiho, Lilian Ebele Chris-Ozoko, Godstime Jesukobiruo Ibada, Sylvester Ifeakachukwu Okuepusu, Favour Isioma Ikukaiwe, Winnie Taiye Ogwu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Laboratory Animal Research
Subjects:
Lutein
Doxorubicin
Steroidogenesis
Testicular toxicity
Autophagy
Online Access:https://doi.org/10.1186/s42826-025-00249-3
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