New Complex of Salinomycin with Hg(II)—Synthesis and Characterization
Salinomycin is a polyether ionophorous antibiotic with promising antineoplastic properties. Published studies have revealed that the compound also exerts pronounced antidotal activity against cadmium (Cd) and lead (Pb) intoxications. It has been proven that salinomycin with Cd(II) forms a coordinati...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/13/7/220 |
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| Summary: | Salinomycin is a polyether ionophorous antibiotic with promising antineoplastic properties. Published studies have revealed that the compound also exerts pronounced antidotal activity against cadmium (Cd) and lead (Pb) intoxications. It has been proven that salinomycin with Cd(II) forms a coordination compound of a composition [Cd(C<sub>42</sub>H<sub>69</sub>O<sub>11</sub>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>] and an octahedral molecular geometry, while the coordination compound of the antibiotic with Pb(II) has a square pyramidal structure and composition [Pb(C<sub>42</sub>H<sub>69</sub>O<sub>11</sub>)(NO<sub>3</sub>)]. To date, there is no published information about the ability of salinomycin to form complexes with the mercury ion (Hg(II)). Herein, we report, for the first time, a synthetic procedure for a complex compound of salinomycin with Hg(II). The coordination compound was characterized by a variety of methods, such as elemental analysis, attenuated total reflectance–Fourier transform infrared spectroscopy (ATR-FTIR), electrospray ionization–mass spectrometry (ESI-MS), powder X-ray diffraction, nuclear magnetic resonance spectroscopy (NMR), thermogravimetry with differential thermal analysis (TG-DTA), and thermogravimetry with mass spectrometry (TG-MS). The elemental analysis data revealed that the new compound is of the chemical composition [Hg(C<sub>42</sub>H<sub>69</sub>O<sub>11</sub>)(H<sub>2</sub>O)(OH)]. Based on the results from the spectral analyses, the most probable structure of the complex was proposed. |
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| ISSN: | 2304-6740 |