Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis.
The role of cognitive domain dysfunction with respect to vocational changes in persons with Clinically Isolated Syndrome (CIS) and early Relapsing Remitting Multiple Sclerosis (eRRMS) is insufficiently known. We investigated thirty-three patients--14 CIS, 19 eRRMS -, mean (standard deviation [SD]) t...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096444&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850191736687558656 |
|---|---|
| author | Peter Joseph Jongen Keith Wesnes Björn van Geel Paul Pop Evert Sanders Hans Schrijver Leo H Visser H Jacobus Gilhuis Ludovicus G Sinnige Augustina M Brands COGNISEC Study Group |
| author_facet | Peter Joseph Jongen Keith Wesnes Björn van Geel Paul Pop Evert Sanders Hans Schrijver Leo H Visser H Jacobus Gilhuis Ludovicus G Sinnige Augustina M Brands COGNISEC Study Group |
| author_sort | Peter Joseph Jongen |
| collection | DOAJ |
| description | The role of cognitive domain dysfunction with respect to vocational changes in persons with Clinically Isolated Syndrome (CIS) and early Relapsing Remitting Multiple Sclerosis (eRRMS) is insufficiently known. We investigated thirty-three patients--14 CIS, 19 eRRMS -, mean (standard deviation [SD]) time since diagnosis 13.5 (4.8) months and mean (SD) Expanded Disability Status Scale (EDSS) score 1.3 (1.1). Patients were assessed on the CDR System, a set of automated tests of cognitive function, which yielded scores for Power of Attention (ms), Continuity of Attention (#), Working Memory (SI), Episodic Memory (#) and Speed of Memory (ms). Work-related items and the confounding variables fatigue, depression, disease impact and self-efficacy, were assessed by self-report questionnaires. Patients had poorer Power of Attention compared to normative data (1187 [161.5] vs. 1070 [98.6]; P<0.0001) and slower Speed of Memory (4043 [830.6]) vs. 2937 [586.1]; P<0.0001). Power of Attention (Pearson r = -0.42; P<0.04), Working Memory (r = 0.42; P<0.04) and depression r = -0.41; P<0.05) correlated with number of days worked per week. Fatigue (r = -0.56; P<0.005), self-efficacy (r = 0.56; P<0.005) and disease impact (r = -0.46; P<0.05) correlated with number of hours worked per week. Persons who wished to work less had poorer Power of Attention (1247 vs. 1116 ms; P<0.02), those who wished to change job had poorer Episodic Memory (1.35 vs. 1.57; p<0.03). People who reduced working hours within 12 months after diagnosis had higher fatigue and disease impact, and lower self-efficacy. The findings of this pilot study indicate that one year after the diagnosis of CIS and RRMS Power of Attention and Speed of Memory are reduced, that Power of Attention and Memory are associated with a capability of working less hours, and that fatigue, depression and disease impact may negatively, and self-efficacy positively affect working hours. |
| format | Article |
| id | doaj-art-fa57356f940f46e8bf0f73eafed3c2cf |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fa57356f940f46e8bf0f73eafed3c2cf2025-08-20T02:14:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9644410.1371/journal.pone.0096444Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis.Peter Joseph JongenKeith WesnesBjörn van GeelPaul PopEvert SandersHans SchrijverLeo H VisserH Jacobus GilhuisLudovicus G SinnigeAugustina M BrandsCOGNISEC Study GroupThe role of cognitive domain dysfunction with respect to vocational changes in persons with Clinically Isolated Syndrome (CIS) and early Relapsing Remitting Multiple Sclerosis (eRRMS) is insufficiently known. We investigated thirty-three patients--14 CIS, 19 eRRMS -, mean (standard deviation [SD]) time since diagnosis 13.5 (4.8) months and mean (SD) Expanded Disability Status Scale (EDSS) score 1.3 (1.1). Patients were assessed on the CDR System, a set of automated tests of cognitive function, which yielded scores for Power of Attention (ms), Continuity of Attention (#), Working Memory (SI), Episodic Memory (#) and Speed of Memory (ms). Work-related items and the confounding variables fatigue, depression, disease impact and self-efficacy, were assessed by self-report questionnaires. Patients had poorer Power of Attention compared to normative data (1187 [161.5] vs. 1070 [98.6]; P<0.0001) and slower Speed of Memory (4043 [830.6]) vs. 2937 [586.1]; P<0.0001). Power of Attention (Pearson r = -0.42; P<0.04), Working Memory (r = 0.42; P<0.04) and depression r = -0.41; P<0.05) correlated with number of days worked per week. Fatigue (r = -0.56; P<0.005), self-efficacy (r = 0.56; P<0.005) and disease impact (r = -0.46; P<0.05) correlated with number of hours worked per week. Persons who wished to work less had poorer Power of Attention (1247 vs. 1116 ms; P<0.02), those who wished to change job had poorer Episodic Memory (1.35 vs. 1.57; p<0.03). People who reduced working hours within 12 months after diagnosis had higher fatigue and disease impact, and lower self-efficacy. The findings of this pilot study indicate that one year after the diagnosis of CIS and RRMS Power of Attention and Speed of Memory are reduced, that Power of Attention and Memory are associated with a capability of working less hours, and that fatigue, depression and disease impact may negatively, and self-efficacy positively affect working hours.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096444&type=printable |
| spellingShingle | Peter Joseph Jongen Keith Wesnes Björn van Geel Paul Pop Evert Sanders Hans Schrijver Leo H Visser H Jacobus Gilhuis Ludovicus G Sinnige Augustina M Brands COGNISEC Study Group Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis. PLoS ONE |
| title | Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis. |
| title_full | Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis. |
| title_fullStr | Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis. |
| title_full_unstemmed | Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis. |
| title_short | Relationship between working hours and power of attention, memory, fatigue, depression and self-efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis. |
| title_sort | relationship between working hours and power of attention memory fatigue depression and self efficacy one year after diagnosis of clinically isolated syndrome and relapsing remitting multiple sclerosis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096444&type=printable |
| work_keys_str_mv | AT peterjosephjongen relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT keithwesnes relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT bjornvangeel relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT paulpop relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT evertsanders relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT hansschrijver relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT leohvisser relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT hjacobusgilhuis relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT ludovicusgsinnige relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT augustinambrands relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis AT cognisecstudygroup relationshipbetweenworkinghoursandpowerofattentionmemoryfatiguedepressionandselfefficacyoneyearafterdiagnosisofclinicallyisolatedsyndromeandrelapsingremittingmultiplesclerosis |