Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology
Colon cancer (CC) is the third most frequent neoplasm, with a considerably high mortality rate. Due to the side effects of conventional forms of CC treatment (surgery, chemotherapy, and radiotherapy), several studies have focused on the use of medicinal plant derivatives to provide a green therapy f...
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| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | https://www.mdpi.com/2218-0532/93/1/1 |
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| author | Manuel López-Cabanillas Lomelí Alexandra Tijerina-Sáenz David Gilberto García-Hernández Marcelo Hernández-Salazar Rogelio Salas García José Luis González-Llerena María Julia Verde-Star Anthonny Cordero-Díaz Michel Stéphane Heya |
| author_facet | Manuel López-Cabanillas Lomelí Alexandra Tijerina-Sáenz David Gilberto García-Hernández Marcelo Hernández-Salazar Rogelio Salas García José Luis González-Llerena María Julia Verde-Star Anthonny Cordero-Díaz Michel Stéphane Heya |
| author_sort | Manuel López-Cabanillas Lomelí |
| collection | DOAJ |
| description | Colon cancer (CC) is the third most frequent neoplasm, with a considerably high mortality rate. Due to the side effects of conventional forms of CC treatment (surgery, chemotherapy, and radiotherapy), several studies have focused on the use of medicinal plant derivatives to provide a green therapy for CC; although phytochemicals have shown promising results against CC, translating the results obtained in vitro and in vivo to the clinical setting remains a challenge. Indeed, like other orally applied medicines, medicinal plant derivatives have to cross different physiological barriers to reach the CC microenvironment, which considerably limits their dose-dependent therapeutic efficacy. On the other hand, phytocompounds are not free from biopharmaceutical drawbacks, so novel strategies using nanoparticles (NPs) have been proposed to overcome the physiological barriers of the body and provide controlled release of actives of interest. Accordingly, the current review provides an overview and discussion on the predisposing factors to CC and conventional treatment, the use of medicinal plants in CC treatment, and the advantages provided by NPs in the treatment of CC. |
| format | Article |
| id | doaj-art-fa5730e6b7dc4ab2b630c020075dc1de |
| institution | Kabale University |
| issn | 0036-8709 2218-0532 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj-art-fa5730e6b7dc4ab2b630c020075dc1de2025-08-20T03:44:04ZengMDPI AGScientia Pharmaceutica0036-87092218-05322024-12-01931110.3390/scipharm93010001Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using NanotechnologyManuel López-Cabanillas Lomelí0Alexandra Tijerina-Sáenz1David Gilberto García-Hernández2Marcelo Hernández-Salazar3Rogelio Salas García4José Luis González-Llerena5María Julia Verde-Star6Anthonny Cordero-Díaz7Michel Stéphane Heya8Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Ave. Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolas de los Garza 64460, Nuevo León, MexicoFacultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Ave. Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolas de los Garza 64460, Nuevo León, MexicoFacultad de Ciencias Biológicas, Departamento de Química, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Nuevo León, MexicoFacultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Ave. Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolas de los Garza 64460, Nuevo León, MexicoFacultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Ave. Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolas de los Garza 64460, Nuevo León, MexicoFacultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Ave. Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolas de los Garza 64460, Nuevo León, MexicoFacultad de Ciencias Biológicas, Departamento de Química, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Nuevo León, MexicoFacultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Nuevo León, MexicoFacultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Ave. Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolas de los Garza 64460, Nuevo León, MexicoColon cancer (CC) is the third most frequent neoplasm, with a considerably high mortality rate. Due to the side effects of conventional forms of CC treatment (surgery, chemotherapy, and radiotherapy), several studies have focused on the use of medicinal plant derivatives to provide a green therapy for CC; although phytochemicals have shown promising results against CC, translating the results obtained in vitro and in vivo to the clinical setting remains a challenge. Indeed, like other orally applied medicines, medicinal plant derivatives have to cross different physiological barriers to reach the CC microenvironment, which considerably limits their dose-dependent therapeutic efficacy. On the other hand, phytocompounds are not free from biopharmaceutical drawbacks, so novel strategies using nanoparticles (NPs) have been proposed to overcome the physiological barriers of the body and provide controlled release of actives of interest. Accordingly, the current review provides an overview and discussion on the predisposing factors to CC and conventional treatment, the use of medicinal plants in CC treatment, and the advantages provided by NPs in the treatment of CC.https://www.mdpi.com/2218-0532/93/1/1colorectal cancerphytochemicalstherapeutic efficacyphysiological barriersnanoparticles |
| spellingShingle | Manuel López-Cabanillas Lomelí Alexandra Tijerina-Sáenz David Gilberto García-Hernández Marcelo Hernández-Salazar Rogelio Salas García José Luis González-Llerena María Julia Verde-Star Anthonny Cordero-Díaz Michel Stéphane Heya Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology Scientia Pharmaceutica colorectal cancer phytochemicals therapeutic efficacy physiological barriers nanoparticles |
| title | Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology |
| title_full | Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology |
| title_fullStr | Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology |
| title_full_unstemmed | Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology |
| title_short | Colon Cancer: Overview on Improved Therapeutic Potential of Plant-Based Compounds Using Nanotechnology |
| title_sort | colon cancer overview on improved therapeutic potential of plant based compounds using nanotechnology |
| topic | colorectal cancer phytochemicals therapeutic efficacy physiological barriers nanoparticles |
| url | https://www.mdpi.com/2218-0532/93/1/1 |
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