Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery
In recent decades, nose-to-brain drug delivery has shown effectiveness in treating many central nervous system diseases. Intranasally administered drugs can be delivered to the brain through the olfactory and trigeminal pathways that bypass the blood–brain barrier. However, nose-to-brain drug delive...
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MDPI AG
2025-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/5/615 |
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| author | Thi-Thao-Linh Nguyen Van-An Duong |
| author_facet | Thi-Thao-Linh Nguyen Van-An Duong |
| author_sort | Thi-Thao-Linh Nguyen |
| collection | DOAJ |
| description | In recent decades, nose-to-brain drug delivery has shown effectiveness in treating many central nervous system diseases. Intranasally administered drugs can be delivered to the brain through the olfactory and trigeminal pathways that bypass the blood–brain barrier. However, nose-to-brain drug delivery is challenging due to the inadequate nasal mucosa absorption of drugs and the short retention time of the intranasal formulations. These problems can be minimized through the use of nano-drug delivery systems, such as micelles, polymeric nanoparticles, nanoemulsions, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers. They can enhance the drug’s bioavailability in the brain via increases in drug solubility, permeation, and stability. Nose-to-brain nano-drug delivery systems have been evaluated in vivo by a number of research groups. This review aims to provide an overview of nose-to-brain delivery and recent advances in the development of nano-drug delivery systems for delivering drugs from the nose to the brain to improve the treatment of some central nervous system diseases. |
| format | Article |
| id | doaj-art-fa56c6a2d0c84e51b85303663550e908 |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-fa56c6a2d0c84e51b85303663550e9082025-08-20T03:14:36ZengMDPI AGPharmaceuticals1424-82472025-04-0118561510.3390/ph18050615Advancements in Nanocarrier Systems for Nose-to-Brain Drug DeliveryThi-Thao-Linh Nguyen0Van-An Duong1Institute of Pharmaceutical Education and Research, Binh Duong University, Thu Dau Mot City 820000, Binh Duong, VietnamThe Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USAIn recent decades, nose-to-brain drug delivery has shown effectiveness in treating many central nervous system diseases. Intranasally administered drugs can be delivered to the brain through the olfactory and trigeminal pathways that bypass the blood–brain barrier. However, nose-to-brain drug delivery is challenging due to the inadequate nasal mucosa absorption of drugs and the short retention time of the intranasal formulations. These problems can be minimized through the use of nano-drug delivery systems, such as micelles, polymeric nanoparticles, nanoemulsions, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers. They can enhance the drug’s bioavailability in the brain via increases in drug solubility, permeation, and stability. Nose-to-brain nano-drug delivery systems have been evaluated in vivo by a number of research groups. This review aims to provide an overview of nose-to-brain delivery and recent advances in the development of nano-drug delivery systems for delivering drugs from the nose to the brain to improve the treatment of some central nervous system diseases.https://www.mdpi.com/1424-8247/18/5/615nose-to-brainnanoparticlesmicellesemulsionsliposomesSLNs |
| spellingShingle | Thi-Thao-Linh Nguyen Van-An Duong Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery Pharmaceuticals nose-to-brain nanoparticles micelles emulsions liposomes SLNs |
| title | Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery |
| title_full | Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery |
| title_fullStr | Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery |
| title_full_unstemmed | Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery |
| title_short | Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery |
| title_sort | advancements in nanocarrier systems for nose to brain drug delivery |
| topic | nose-to-brain nanoparticles micelles emulsions liposomes SLNs |
| url | https://www.mdpi.com/1424-8247/18/5/615 |
| work_keys_str_mv | AT thithaolinhnguyen advancementsinnanocarriersystemsfornosetobraindrugdelivery AT vananduong advancementsinnanocarriersystemsfornosetobraindrugdelivery |