Single-Nucleus and Spatial Transcriptomics Revealing Host Response Differences Triggered by Mutated Virus in Severe Dengue

Single-Nucleus and Spatial Transcriptomics Revealing Host Response Differences Triggered by Mutated Virus in Severe Dengue

Dengue virus (DENV) infection causes various disease manifestations ranging from an asymptomatic state to severe, life-threatening dengue. Despite intensive research, the molecular mechanisms underlying the abnormal host responses and severe disease symptoms caused by evolved DENV strains is not ful...

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Bibliographic Details
Main Authors: Qian Chen, Yizhen Yuan, Fangzhou Cai, Zhe Li, Qiang Wei, Wei Wang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Viruses
Subjects:
dengue virus
cumulative mutation
severe dengue
single-nucleus RNA sequencing
spatial transcriptomics
Nrg4
Online Access:https://www.mdpi.com/1999-4915/16/11/1779
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