The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting postmenopausal women. This study investigated the effects of intermittent fasting (IF) on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with RA. This 8-week randomiz...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86734-0 |
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| author | Aryan Tavakoli Camellia Akhgarjand Hastimansooreh Ansar Hirad Houjaghani Amirhossein Khormani Kurosh Djafarian Abdolrahman Rostamian Mahsa Ranjbar Gholamreza Mohammadi Farsani |
| author_facet | Aryan Tavakoli Camellia Akhgarjand Hastimansooreh Ansar Hirad Houjaghani Amirhossein Khormani Kurosh Djafarian Abdolrahman Rostamian Mahsa Ranjbar Gholamreza Mohammadi Farsani |
| author_sort | Aryan Tavakoli |
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| description | Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting postmenopausal women. This study investigated the effects of intermittent fasting (IF) on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with RA. This 8-week randomized controlled trial included 44 postmenopausal women with RA divided into an intervention group following a 16:8 IF diet and a control group maintaining their usual diet and received recommendations for healthy eating. Inflammatory indices, oxidative stress markers, and liver enzymes were measured at baseline and post intervention. The IF group showed significant decreases in serum malondialdehyde (MDA) levels (P = 0.02) and neutrophil-to-lymphocyte ratio (P = 0.018) and increased catalase levels (P = 0.004) compared to the control group. Liver enzymes aspartate transaminase (AST) and alanine transaminase (ALT) also decreased significantly in the IF group (P = 0.02 and P = 0.03, respectively). No significant differences were observed in the other measured parameters between groups. In conclusion, the 16:8 IF diet demonstrated beneficial effects on some oxidative stress markers, inflammatory indices, and liver enzymes in postmenopausal, overweight, and obese women with RA. These findings suggest that IF may be an effective non-pharmacological intervention for managing RA in this population, potentially addressing both primary disease symptoms and associated metabolic complications. Further research is needed to elucidate the long-term effects and mechanisms of IF in the management of RA. |
| format | Article |
| id | doaj-art-fa54e398a5954815a21fd3bc4359524d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-fa54e398a5954815a21fd3bc4359524d2025-01-19T12:19:49ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86734-0The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trialAryan Tavakoli0Camellia Akhgarjand1Hastimansooreh Ansar2Hirad Houjaghani3Amirhossein Khormani4Kurosh Djafarian5Abdolrahman Rostamian6Mahsa Ranjbar7Gholamreza Mohammadi Farsani8Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesFaculty of Medicine, Iran University of Medical Sciences (IUMS)Department of Surgery, Shariati Hospital, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesRheumatology Research Center, Imam Khomeini Complex, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesAbstract Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting postmenopausal women. This study investigated the effects of intermittent fasting (IF) on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with RA. This 8-week randomized controlled trial included 44 postmenopausal women with RA divided into an intervention group following a 16:8 IF diet and a control group maintaining their usual diet and received recommendations for healthy eating. Inflammatory indices, oxidative stress markers, and liver enzymes were measured at baseline and post intervention. The IF group showed significant decreases in serum malondialdehyde (MDA) levels (P = 0.02) and neutrophil-to-lymphocyte ratio (P = 0.018) and increased catalase levels (P = 0.004) compared to the control group. Liver enzymes aspartate transaminase (AST) and alanine transaminase (ALT) also decreased significantly in the IF group (P = 0.02 and P = 0.03, respectively). No significant differences were observed in the other measured parameters between groups. In conclusion, the 16:8 IF diet demonstrated beneficial effects on some oxidative stress markers, inflammatory indices, and liver enzymes in postmenopausal, overweight, and obese women with RA. These findings suggest that IF may be an effective non-pharmacological intervention for managing RA in this population, potentially addressing both primary disease symptoms and associated metabolic complications. Further research is needed to elucidate the long-term effects and mechanisms of IF in the management of RA.https://doi.org/10.1038/s41598-025-86734-0Intermittent fastingRheumatoid arthritisOxidative stressInflammationPostmenopausal women |
| spellingShingle | Aryan Tavakoli Camellia Akhgarjand Hastimansooreh Ansar Hirad Houjaghani Amirhossein Khormani Kurosh Djafarian Abdolrahman Rostamian Mahsa Ranjbar Gholamreza Mohammadi Farsani The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial Scientific Reports Intermittent fasting Rheumatoid arthritis Oxidative stress Inflammation Postmenopausal women |
| title | The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial |
| title_full | The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial |
| title_fullStr | The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial |
| title_full_unstemmed | The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial |
| title_short | The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial |
| title_sort | effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal overweight and obese women with rheumatoid arthritis a randomized controlled trial |
| topic | Intermittent fasting Rheumatoid arthritis Oxidative stress Inflammation Postmenopausal women |
| url | https://doi.org/10.1038/s41598-025-86734-0 |
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