The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis
PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been kn...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3608315 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849694515457163264 |
|---|---|
| author | Siyue Du Nicole Wagner Kay-Dietrich Wagner |
| author_facet | Siyue Du Nicole Wagner Kay-Dietrich Wagner |
| author_sort | Siyue Du |
| collection | DOAJ |
| description | PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark of cancer, and our recent works also demonstrate that vascular-specific PPAR beta/delta overexpression promotes tumor angiogenesis and progression in vivo. In this review, we will mainly focus on the role of PPAR beta/delta in tumor angiogenesis linked to the tumor microenvironment to further facilitate tumor progression and metastasis. Moreover, the crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will also be discussed, and the network of interplay between them will further be established in the review. |
| format | Article |
| id | doaj-art-fa54a1fea63141af9e0802e623e9ead4 |
| institution | DOAJ |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-fa54a1fea63141af9e0802e623e9ead42025-08-20T03:20:03ZengWileyPPAR Research1687-47571687-47652020-01-01202010.1155/2020/36083153608315The Emerging Role of PPAR Beta/Delta in Tumor AngiogenesisSiyue Du0Nicole Wagner1Kay-Dietrich Wagner2Université Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FranceUniversité Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FranceUniversité Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FrancePPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark of cancer, and our recent works also demonstrate that vascular-specific PPAR beta/delta overexpression promotes tumor angiogenesis and progression in vivo. In this review, we will mainly focus on the role of PPAR beta/delta in tumor angiogenesis linked to the tumor microenvironment to further facilitate tumor progression and metastasis. Moreover, the crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will also be discussed, and the network of interplay between them will further be established in the review.http://dx.doi.org/10.1155/2020/3608315 |
| spellingShingle | Siyue Du Nicole Wagner Kay-Dietrich Wagner The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis PPAR Research |
| title | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
| title_full | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
| title_fullStr | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
| title_full_unstemmed | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
| title_short | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
| title_sort | emerging role of ppar beta delta in tumor angiogenesis |
| url | http://dx.doi.org/10.1155/2020/3608315 |
| work_keys_str_mv | AT siyuedu theemergingroleofpparbetadeltaintumorangiogenesis AT nicolewagner theemergingroleofpparbetadeltaintumorangiogenesis AT kaydietrichwagner theemergingroleofpparbetadeltaintumorangiogenesis AT siyuedu emergingroleofpparbetadeltaintumorangiogenesis AT nicolewagner emergingroleofpparbetadeltaintumorangiogenesis AT kaydietrichwagner emergingroleofpparbetadeltaintumorangiogenesis |