CRISPR/CasRx-mediated RNA knockdown targeting β-catenin and Ihh signaling alleviates osteoarthritis

CRISPR/CasRx-mediated RNA knockdown targeting β-catenin and Ihh signaling alleviates osteoarthritis

Osteoarthritis (OA) is a chronic degenerative joint disease. Currently, OA is incurable. Abnormal activation of canonical Wnt/β-catenin or Indian hedgehog (Ihh) signaling could lead to OA development and progression. This study aimed to determine if targeting β-catenin and Ihh signaling could yield...

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Bibliographic Details
Main Authors: Xingyun Huang, Jiamin Yu, Shixue Gou, Hongyu Qin, William W. Lu, Zhen Li, Liping Tong, Di Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-07-01
Series:Genes and Diseases
Subjects:
CRISPR/CasRx
Ctnnb1
Indian hedgehog
Osteoarthritis
Smoothened
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224002654
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