A CD Study of a Structure-Based Selection of <i>N</i>-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence

A CD Study of a Structure-Based Selection of <i>N</i>-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence

Herein, we report the structure-based selection via molecular docking of four <i>N</i>-heterocyclic bis-carbene gold(I) complexes, whose potential as ligands for the hTel23 G-quadruplex structure has been investigated using circular dichroism (CD) spectroscopy, CD melting, and polyacryla...

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Bibliographic Details
Main Authors: Maria Marzano, Filippo Prencipe, Pietro Delre, Giuseppe Felice Mangiatordi, Gabriele Travagliante, Luisa Ronga, Gennaro Piccialli, Michele Saviano, Stefano D’Errico, Diego Tesauro, Giorgia Oliviero
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
auranofin
cancer
chemotherapy
<i>N</i>-heterocyclic carbene gold(I) complexes
G-quadruplex
CD spectroscopy
Online Access:https://www.mdpi.com/1420-3049/29/22/5446
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