Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond
Abstract Caspases are crucial regulators of programmed cell death, mediating pathways such as apoptosis, pyroptosis, necroptosis and ferroptosis. Their activity is intricately controlled by epigenetic modifications, molecular interactions and post-translational changes, reflecting their central role...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-06-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-025-01470-9 |
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| _version_ | 1849238660633853952 |
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| author | So Hee Dho Minjeong Cho Wonjin Woo Seolhee Jeong Lark Kyun Kim |
| author_facet | So Hee Dho Minjeong Cho Wonjin Woo Seolhee Jeong Lark Kyun Kim |
| author_sort | So Hee Dho |
| collection | DOAJ |
| description | Abstract Caspases are crucial regulators of programmed cell death, mediating pathways such as apoptosis, pyroptosis, necroptosis and ferroptosis. Their activity is intricately controlled by epigenetic modifications, molecular interactions and post-translational changes, reflecting their central role in cellular homeostasis and disease mechanisms. Dysregulated caspase functions are linked to a wide array of conditions, including cancer, neurodegenerative disorders and inflammatory diseases, establishing their importance as potential therapeutic targets. The roles and regulation of caspases across subcellular compartments and their molecular interactions provide critical insights into the complexity of programmed cell death. Here, this review synthesizes current knowledge on the diverse functions of caspases, offering a comprehensive foundation for exploring innovative therapeutic strategies. |
| format | Article |
| id | doaj-art-fa4c5fec572c41888b8dafaad8913eb8 |
| institution | Kabale University |
| issn | 2092-6413 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj-art-fa4c5fec572c41888b8dafaad8913eb82025-08-20T04:01:26ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132025-06-015761121113210.1038/s12276-025-01470-9Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyondSo Hee Dho0Minjeong Cho1Wonjin Woo2Seolhee Jeong3Lark Kyun Kim4Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract Caspases are crucial regulators of programmed cell death, mediating pathways such as apoptosis, pyroptosis, necroptosis and ferroptosis. Their activity is intricately controlled by epigenetic modifications, molecular interactions and post-translational changes, reflecting their central role in cellular homeostasis and disease mechanisms. Dysregulated caspase functions are linked to a wide array of conditions, including cancer, neurodegenerative disorders and inflammatory diseases, establishing their importance as potential therapeutic targets. The roles and regulation of caspases across subcellular compartments and their molecular interactions provide critical insights into the complexity of programmed cell death. Here, this review synthesizes current knowledge on the diverse functions of caspases, offering a comprehensive foundation for exploring innovative therapeutic strategies.https://doi.org/10.1038/s12276-025-01470-9 |
| spellingShingle | So Hee Dho Minjeong Cho Wonjin Woo Seolhee Jeong Lark Kyun Kim Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond Experimental and Molecular Medicine |
| title | Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond |
| title_full | Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond |
| title_fullStr | Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond |
| title_full_unstemmed | Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond |
| title_short | Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond |
| title_sort | caspases as master regulators of programmed cell death apoptosis pyroptosis and beyond |
| url | https://doi.org/10.1038/s12276-025-01470-9 |
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